Results 51 to 60 of about 211,652 (303)

Emerging Evidence Highlighting the Importance of Redox Dysregulation in the Pathogenesis of Amyotrophic Lateral Sclerosis (ALS)

Frontiers in Cellular Neuroscience, 2021
The cellular redox state, or balance between cellular oxidation and reduction reactions, serves as a vital antioxidant defence system that is linked to all important cellular activities.
Cyril Jones Jagaraj, Sonam Parakh, Julie D. Atkin, Julie D. Atkin   +3 more
doaj   +1 more source

The Yin and Yang of redox regulation [PDF]

Redox Report, 2013
Mammalian cells produce reactive oxygen and nitrogen species (ROS/RNOS) in response to an oxidative environment. Powerful antioxidant mechanisms have been developed in order to avoid oxidative stress by contributing to the maintenance of redox homeostasis.
Olsen, Lars Folke; id_orcid 0000-0001-7391-2340, Issinger, Olaf-Georg, Guerra, Barbara; id_orcid 0000-0003-1136-2413   +2 more
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Characterisation of components and mechanisms involved in redox-regulation of protein import into chloroplasts [PDF]

, 2009
The vast majority of chloroplast proteins is encoded in the nucleus and thus has to be posttranslationally imported into the organelle, a process that is facilitated by two multimeric protein machineries, the Toc and Tic complexes (translocon at the ...
Stengel, Anna
core  

Dynamic Redox Regulation of IL-4 Signaling. [PDF]

PLoS Computational Biology, 2015
Quantifying the magnitude and dynamics of protein oxidation during cell signaling is technically challenging. Computational modeling provides tractable, quantitative methods to test hypotheses of redox mechanisms that may be simultaneously operative ...
Gaurav Dwivedi, Margaret A Gran, Pritha Bagchi, Melissa L Kemp   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The redox-sensitive transcription factor Rap2.4a controls nuclear expression of 2-Cys peroxiredoxin A and other chloroplast antioxidant enzymes

, 2008
Shaikhali J, Heiber I, Seidel T, et al. The redox-sensitive transcription factor Rap2.4a controls nuclear expression of 2-Cys peroxiredoxin A and other chloroplast antioxidant enzymes. BMC Plant Biology.
Thorsten Seidel, Birkmann Stefan, Hiltscher, Heiko, Baier Margarete, Shaikhali, Jehad, Birkmann, Stefan, Heiber Isabelle, Stroeher, Elke, Dietz Karl-Josef, Karl-Josef Dietz, Baier, Margarete, Margarete Baier, Heiber, Isabelle, Hiltscher Heiko, Shaikhali Jehad, Heiko Hiltscher, Dietz, Karl-Josef, Isabelle Heiber, Elke Ströher, Seidel Thorsten, Jehad Shaikhali, Seidel, Thorsten, Ströher Elke, Stefan Birkmann   +23 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Thioredoxin and Glutaredoxin: General Aspects and Involvement in Redox Regulation

, 2001
Redox-active thiols play a major role in the mechanisms of essential biosynthetic and repair enzymes, defense against oxidative stress or thiol redox control of transcription, translation and enzyme activity.
Arne Holmgren, Holmgren, A
core   +1 more source

The Stallion Spermatozoa: A Valuable Model to Help Understand the Interplay between Metabolism and Redox (De)regulation in Sperm Cells [PDF]

, 2022
Significance: Proper functionality of the spermatozoa depends on the tight regulation of their redox status; at the same time these cells are highly energy demanding and in the energetic metabolism, principally in the electron transport chain in the ...
Oflaherty C., Gil M. C., Martin Cano F. E., Gaitskell-Phillips G., Ortega Ferrusola C., Ortiz Rodriguez J. M., Pena F. J.   +6 more
core   +1 more source