Results 231 to 240 of about 171,869 (285)
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Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 2016
BACKGROUND Hyper-CVAD is the treatment for patients with acute lymphoblastic leukemia in our institution. OBJECTIVE To evaluate the impact of single nucleotide polymorphisms at genes associated with methotrexate metabolism on survival.
M. Candelaria +5 more
semanticscholar +1 more source
BACKGROUND Hyper-CVAD is the treatment for patients with acute lymphoblastic leukemia in our institution. OBJECTIVE To evaluate the impact of single nucleotide polymorphisms at genes associated with methotrexate metabolism on survival.
M. Candelaria +5 more
semanticscholar +1 more source
Birth Defects Research Part A: Clinical and Molecular Teratology, 2008
AbstractBACKGROUND: The reduced folate carrier (RFC1) is a ubiquitously expressed integral membrane protein that mediates delivery of 5‐methyltetrahydrofolate into mammalian cells. In this study, embryonic/fetal development is characterized in an RFC1 knockout mouse model in which pregnant dams receive different levels of folate supplementation ...
Janee, Gelineau-van Waes +7 more
openaire +2 more sources
AbstractBACKGROUND: The reduced folate carrier (RFC1) is a ubiquitously expressed integral membrane protein that mediates delivery of 5‐methyltetrahydrofolate into mammalian cells. In this study, embryonic/fetal development is characterized in an RFC1 knockout mouse model in which pregnant dams receive different levels of folate supplementation ...
Janee, Gelineau-van Waes +7 more
openaire +2 more sources
2002
Several distinct routes for the uptake of folates and antifolates have been reported. Transport via the reduced folate carrier (RFC) is a carrier-mediated process that generates folate uptake through a bi-directional anion exchange mechanism (1,2). The RFC is characterized by a high affinity (Km: 1–10 µM) for reduced folates and MTX, whereas it has a ...
Mauritz, R. +5 more
openaire +3 more sources
Several distinct routes for the uptake of folates and antifolates have been reported. Transport via the reduced folate carrier (RFC) is a carrier-mediated process that generates folate uptake through a bi-directional anion exchange mechanism (1,2). The RFC is characterized by a high affinity (Km: 1–10 µM) for reduced folates and MTX, whereas it has a ...
Mauritz, R. +5 more
openaire +3 more sources
International Journal of Cancer, 1997
Methotrexate transport deficiency due to decreased reduced folate carrier (RFC) activity has been observed in several cell lines selected for resistance to methotrexate (MTX). Since MTX resistance is multifactorial, however, it is difficult to quantify the relative importance of changes in RFC activity in selected cell lines and even more so to ...
J A, Moscow +5 more
openaire +2 more sources
Methotrexate transport deficiency due to decreased reduced folate carrier (RFC) activity has been observed in several cell lines selected for resistance to methotrexate (MTX). Since MTX resistance is multifactorial, however, it is difficult to quantify the relative importance of changes in RFC activity in selected cell lines and even more so to ...
J A, Moscow +5 more
openaire +2 more sources
Reduced folate carrier (RFC-1) gene expression in normal and psoriatic skin
Archives of Dermatological Research, 1998Methotrexate is widely used in the treatment of severe psoriasis. However, little is currently known about the mechanisms underlying its therapeutic activity in the skin. Methotrexate has been shown to be carried into cells through the reduced folate carrier (RFC-1). The recent cloning and characterization of the human gene encoding this transmembranal
E, Sprecher +8 more
openaire +2 more sources
Molecular and cellular biology of the human reduced folate carrier
2001The natural folates are water-soluble members of the B class of vitamins that are essential for cell proliferation and tissue regeneration. Since mammalian cells cannot synthesize folates de novo, tightly regulated and sophisticated cellular uptake processes have evolved to sustain sufficient levels of intracellular tetrahydrofolate cofactors to ...
openaire +2 more sources
Interactions of human reduced folate carrier SLC19A1 with folates and antifolates
Biophysical Journal, 2023Han Zhang, Wonpil Im
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European Journal of Biochemistry, 2000
Human CEM‐7A cells established by gradual deprivation of leucovorin from the growth medium, display 100‐fold overexpression of methotrexate transport activity. We found that this was associated with 10‐fold reduced folate carrier gene amplification and 50‐fold overexpression of both the principal 3 kb reduced folate carrier transcript and, surprisingly,
Drori, S +5 more
openaire +4 more sources
Human CEM‐7A cells established by gradual deprivation of leucovorin from the growth medium, display 100‐fold overexpression of methotrexate transport activity. We found that this was associated with 10‐fold reduced folate carrier gene amplification and 50‐fold overexpression of both the principal 3 kb reduced folate carrier transcript and, surprisingly,
Drori, S +5 more
openaire +4 more sources
Clinical Cancer Research, 2005
Abstract Pemetrexed is a novel antifolate with polyglutamate derivatives that are potent inhibitors of thymidylate synthase (TS) and to a lesser extent glycinamide ribonucleotide formyltransferase (GARFT). Conditions that might modulate relative suppression of these sites were assessed by the pattern of hypoxanthine and thymidine ...
Rongbao, Zhao +4 more
openaire +2 more sources
Abstract Pemetrexed is a novel antifolate with polyglutamate derivatives that are potent inhibitors of thymidylate synthase (TS) and to a lesser extent glycinamide ribonucleotide formyltransferase (GARFT). Conditions that might modulate relative suppression of these sites were assessed by the pattern of hypoxanthine and thymidine ...
Rongbao, Zhao +4 more
openaire +2 more sources