Results 241 to 250 of about 4,058,802 (278)
Poultry Science, 2009 The reduced folate carrier (RFC) has been postulated to be a major entity for folate transport activity in humans and other mammals. However, there are limited reports of the importance of RFC in an avian system. In the current study, therefore, the molecular cloning and tissue distribution of RFC, as well as the effect of dietary folate ...
James D. House +2 more
exaly +4 more sources
A Humanized Mouse Model for the Reduced Folate Carrier [PDF]
Molecular Genetics and Metabolism, 2008 The ubiquitously expressed reduced folate carrier (RFC) or SLC19A1 is recognized to be an essential transport system for folates in mammalian cells and tissues. In addition to its generalized role as a folate transporter, RFC provides specialized tissue functions including absorption across intestinal/colonic epithelia, transport across the basolateral
David Patterson +2 more
exaly +3 more sources
Localization of the Murine Reduced Folate Carrier as Assessed by Immunohistochemical Analysis
Biochimica Et Biophysica Acta - Biomembranes, 2001 The reduced folate carrier (RFC1) is a major route for the transport of folates in mammalian cells. The localization of RFC1 in murine tissues was evaluated by immunohistochemical analysis using a polyclonal antibody to the C-terminus of the carrier.
Rongbao Zhao +2 more
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Reduced Folate Carrier Polymorphisms and Neural Tube Defect Risk
Molecular Genetics and Metabolism, 2006The reduced folate carrier (RFCI) is essential for folate transport into cells. Low folate is an important cause of neural tube defects (NTDs), and a single-nucleotide polymorphism (H27R) (80G-->A) in the RFCI gene has been reported to be a NTD risk factor.
Lawrence C Brody +2 more
exaly +4 more sources
Role of reduced folate carrier in intestinal folate uptake
American Journal of Physiology-Cell Physiology, 2006Studies from our laboratory and others have characterized different aspects of the intestinal folate uptake process and have shown that the reduced folate carrier (RFC) is expressed in the gut and plays a role in the uptake process. Little, however, is known about the actual contribution of the RFC system toward total folate uptake by the enterocytes.
Krishnaswamy, Balamurugan, Hamid M, Said
openaire +2 more sources
Reduced Folate Carrier Protein Expression in Osteosarcoma [PDF]
Cancer, 2003 AbstractBACKGROUNDHigh‐dose methotrexate (MTX) is an important component of current protocols for the treatment of osteosarcoma. Although MTX uptake proceeds primarily through the reduced folate carrier (RFC) protein and efflux occurs via multidrug resistance protein 1 (MRP1), RFC protein expression in osteosarcoma remains unexamined.METHODSRFC and ...
Yehuda G Assaraf, Ilan Ifergan
exaly +3 more sources
Birth Defects Research Part A: Clinical and Molecular Teratology, 2008
AbstractBACKGROUND: The reduced folate carrier (RFC1) is a ubiquitously expressed integral membrane protein that mediates delivery of 5‐methyltetrahydrofolate into mammalian cells. In this study, embryonic/fetal development is characterized in an RFC1 knockout mouse model in which pregnant dams receive different levels of folate supplementation ...
Richard H. Finnell +2 more
exaly +3 more sources
AbstractBACKGROUND: The reduced folate carrier (RFC1) is a ubiquitously expressed integral membrane protein that mediates delivery of 5‐methyltetrahydrofolate into mammalian cells. In this study, embryonic/fetal development is characterized in an RFC1 knockout mouse model in which pregnant dams receive different levels of folate supplementation ...
Richard H. Finnell +2 more
exaly +3 more sources