Results 261 to 270 of about 4,058,802 (278)

Other mechanisms to explain the role of reduced folate carrier in cancer

European Journal of Haematology, 2008
Abstract The reduced folate carrier (RFC) is a transmembrane protein that mediates cellular uptake of reduced folates and antifolate drugs, including methotrexate (MTX). Acquired alterations of the RFC gene have been associated with resistance to MTX in cancer cell lines and primary osteosarcomas.
BUDA, GABRIELE, ORCIUOLO E, MAGGINI V, GALIMBERTI, SARA, BARALE, ROBERTO, ROSSI A. M, PETRINI, MARIO   +6 more
openaire   +2 more sources

Differential expression of folate receptor α and reduced folate carrier and effect of folate in ovarian cancer

2010
Ovarian cancer is a common gynecological cancer world-wide and contributes to the highest mortality despite of advances in treatment modalities. There is increasing evidence that diet is a crucial factor in the development and progression of various human cancers.
Ngan, HYS, Chan, HY, Cheung, ANY, Kong, SH, Chan, KYQ, Siu, KY   +5 more
openaire   +1 more source

Identification of mutations in the human reduced folate carrier in patients with folate malabsorption syndrome

Gastroenterology, 2003
Balamurugan Krishnaswamy, Claudio Sandoval, Hamid M. Said   +2 more
openaire   +1 more source

Structural Determinants of Folate and Antifolate Membrane Transport by the Reduced Folate Carrier

2009
Wei Cao, Larry H. Matherly
openaire   +1 more source

pH Dependence of Methotrexate Transport by the Reduced Folate Carrier and the Folate Receptor in L1210 Leukemia Cells: Further Evidence for a Third Route Mediated at Low pH

Biochemical Pharmacology, 1997
Michael J Spinella, Kevin E Brigle, Esteban E Sierra   +2 more
exaly  

G80A Reduced Folate Carrier SNP Modulates Cellular Uptake of Folate and Affords Protection Against Thrombosis via a Non Homocysteine Related Mechanism

Life Sciences, 2005
Mark Lucock, Zoe Yates
exaly  

The H+-Dependent Reduced Folate Carrier 1 of Humans and the Sodium-Dependent Methotrexate Carrier-1 of the Rat Are Orthologs

FEBS Letters, 2004
Carsten Kneuer
exaly  

Genetic Polymorphism (G80A) of Reduced Folate Carrier Gene in Ethnic Populations

Molecular Genetics and Metabolism, 2001
P L, Rady, S, Szucs, R K, Matalon, J, Grady, S D, Hudnall, L H, Kellner, H, Nitowsky   +6 more
openaire   +2 more sources

Comparison of Methotrexate Polyglutamylation in l1210 Leukemia Cells When Influx Is Mediated by the Reduced Folate Carrier or the Folate Receptor: Lack of Evidence for Influx Route-Specific Effects

Biochemical Pharmacology, 1996
Michael J Spinella, Kevin E Brigle, Sarah J Freemantle   +2 more
exaly  

The reduced folate carrier (RFC-1) gene is expressed in the murine epidermis

Archives of Dermatological Research, 1998
E, Sprecher, R, Bergman, H, Sprecher, G, Maor, I, Reiter, N, Krivoy, S, Drori, Y G, Assaraf, R, Friedman-Birnbaum   +8 more
openaire   +2 more sources