Results 241 to 250 of about 171,869 (285)
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Biochemical Pharmacology, 1995
This laboratory previously described an L1210 murine leukemia cell line with a functional defect in the reduced folate carrier and increased expression of folate receptor-beta (F2-MTXrA). This cell line was used to characterize methotrexate (MTX) influx mediated by folate receptor-beta and to compare this with influx mediated by the reduced folate ...
E E, Sierra +3 more
openaire +2 more sources
This laboratory previously described an L1210 murine leukemia cell line with a functional defect in the reduced folate carrier and increased expression of folate receptor-beta (F2-MTXrA). This cell line was used to characterize methotrexate (MTX) influx mediated by folate receptor-beta and to compare this with influx mediated by the reduced folate ...
E E, Sierra +3 more
openaire +2 more sources
Cancer Research, 2013
Abstract The reduced folate carrier (RFC) is the major tissue folate transporter in mammalian cells. RFC is essential for providing folates for biosynthetic pathways leading to nucleotides and amino acids. Clinically relevant antifolates including methotrexate (Mtx), pemetrexed, and pralatrexate are all substrates for RFC and RFC levels ...
Zhanjun Hou +4 more
openaire +1 more source
Abstract The reduced folate carrier (RFC) is the major tissue folate transporter in mammalian cells. RFC is essential for providing folates for biosynthetic pathways leading to nucleotides and amino acids. Clinically relevant antifolates including methotrexate (Mtx), pemetrexed, and pralatrexate are all substrates for RFC and RFC levels ...
Zhanjun Hou +4 more
openaire +1 more source
Increased expression of human reduced folate carrier in fetal Down syndrome brain
2003Down syndrome (trisomy of chromosome 21) (DS) is the most common genetic cause of mental retardation. In our study we employed immunoblotting to evaluate protein expression of reduced folate carrier (hRFC), encoded by a gene localised on chromosome 21, in fetal DS brain.
G, Lubec +4 more
openaire +2 more sources
International Journal of Biological Macromolecules
A specific rheumatoid arthritis (RA)-microenvironment-triggered nanocarrier for RA treatment of a first-line antirheumatic drug (MTX) has been proposed.
L. Dang +5 more
semanticscholar +1 more source
A specific rheumatoid arthritis (RA)-microenvironment-triggered nanocarrier for RA treatment of a first-line antirheumatic drug (MTX) has been proposed.
L. Dang +5 more
semanticscholar +1 more source
Gastroenterology, 2009
G A A b st ra ct s HIF-1α signaling in response to Cdif toxin. Results: Caco-2 cells exposed to Cdif toxin displayed a significant increase in HIF-1α transcription, protein levels and DNA binding. Cdif toxin-induced HIF-1α protein accumulation was attenuated by nitric oxide synthase inhibitors.
Nissar Ahmad Wani, Jyotdeep Kaur
openaire +1 more source
G A A b st ra ct s HIF-1α signaling in response to Cdif toxin. Results: Caco-2 cells exposed to Cdif toxin displayed a significant increase in HIF-1α transcription, protein levels and DNA binding. Cdif toxin-induced HIF-1α protein accumulation was attenuated by nitric oxide synthase inhibitors.
Nissar Ahmad Wani, Jyotdeep Kaur
openaire +1 more source
Reduced folat carrier gene status in colorectal, gastric, and pancreatic cancer
Journal of Clinical Oncology, 2009e13540 Background: Folates play a key role in one-carbon metabolism essential for the biosynthesis of purines, thymidylate and hence DNA replication. Folates and antifolates which cannot traverse membranes must use specific transport systems for their cellular uptake.
Cil, T. +5 more
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Efficient perovskite solar cells via improved carrier management
Nature, 2021Jason J Yoo +2 more
exaly
2010
Ovarian cancer is a common gynecological cancer world-wide and contributes to the highest mortality despite of advances in treatment modalities. There is increasing evidence that diet is a crucial factor in the development and progression of various human cancers.
Ngan, HYS +5 more
openaire +1 more source
Ovarian cancer is a common gynecological cancer world-wide and contributes to the highest mortality despite of advances in treatment modalities. There is increasing evidence that diet is a crucial factor in the development and progression of various human cancers.
Ngan, HYS +5 more
openaire +1 more source