Results 101 to 110 of about 776,097 (338)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Computational reverse mathematics and foundational analysis [PDF]

, 2018
Reverse mathematics studies which subsystems of second order arithmetic are equivalent to key theorems of ordinary, non-set-theoretic mathematics. The main philosophical application of reverse mathematics proposed thus far is foundational analysis, which
Eastaugh, Benedict
core   +1 more source

Nonintegrability, Chaos, and Complexity

, 2000
Two-dimensional driven dissipative flows are generally integrable via a conservation law that is singular at equilibria. Nonintegrable dynamical systems are confined to n*3 dimensions.
Arnol'd, Arnol'd, Arnol'd, Bak, Bak, Bell, Bender, Bennett, Benzi, Bowler, Burns, Constantin, Constantin, Crisanti, Cvitanovic, de Sousa Viera, Eigen, Feigenbaum, Foias, Fornenko, Fredkin, Friedrich, Garey, Gleick, Grinstein, Gunaratne, Hu, Joseph L. McCauley, Koopman, Krug, Küppers, Lindley, Lipton, Lloyd, Lofse, Lorenz, McCauley, McCauley, McCauley, McCauley, McCauley, Moore, Moore, Moore, Morowitz, Olby, Olver, Omohundro, Poincaré, Ruelle, Schuster, She, Tabor, von Neumann, von Neumann, Weinberg, Wigner, Wintner, Young   +58 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Co je na životě tak zvláštního? Příklad redukcionismu René Descarta (What is so special about life? The example of René Descartes‘ reductionism )

Ostium, 2017
History of philosophy offers many examples capable of informing discussions related to questions, topics and problems, which are actual for both philosophy and particular scientific fields. Explanation of the nature of life is such a topic.
Vladimír Vodička
doaj  

The impact of science on metaphysics and its limits [PDF]

, 2006
The paper argues for three theses: (1) Metaphysics depends on science as a source of knowledge. Our current scientific theories commit us to certain metaphysical claims.
Esfeld, Michael
core  

Acute Hemodynamic Effects of Red Cell Volume Reduction in Polycythemia of Cyanotic Congenital Heart Disease [PDF]

, 1970
Amnon Rosenthal, David G. Nathan, Alan T. Marty, Lawrence N. Button, Olli S. Miettinen, Alexander S. Nadas   +5 more
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

SOCIALITY PROBLEM IN THE CONTEXT OF CLASSICAL AND NONCLASSICAL INTERPRETATIONS

Вестник Кемеровского государственного университета, 2014
The paper shows that widespread approaches to studying society by means of allocating only one representative level within it are limited. As a possible the solution to this problem, the author suggests using the integrative approach which realizes the ...
E. O. Gavrilov
doaj