Results 71 to 80 of about 28,838 (266)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Chewing gum and stress reduction [PDF]

Journal of Clinical and Translational Research, 2016
The behavioral effects of chewing gum have been studied for over 80 years and much of the research has been concerned with increases in alertness and attention. Another line of research has addressed the issue of whether chewing gum reduces stress. This topic has been studied in the laboratory, in epidemiological studies and real-life interventions.The
openaire   +2 more sources

2-Nitroimidazole based fluorescent probes for nitroreductase; monitoring reductive stress in cellulo [PDF]

, 2017
Two 2-nitroimidazole-1,8-naphthalimide conjugates, 1 and 2, have been synthesised as fluorescence probes for the detection of reductive stress in HeLa cells.
Elmes, Robert B.P., Bright, Sandra A., X. Ao, R. B. P. Elmes, N. C. Taylor, S. A. Bright, Ao, Xiang, Taylor, N.C.   +7 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Idiopathic male infertility revisited: can redox endophenotypes reframe the ‘idiopathic’ label?

Frontiers in Endocrinology
Male infertility accounts for nearly half of all infertility cases worldwide, yet up to 30-40% of affected men remain categorized as ‘idiopathic’, reflecting limitations of conventional diagnostics such as semen analysis, hormonal profiling, karyotyping,
Pallav Sengupta, Sulagna Dutta, Ralf Henkel, Israel Maldonado Rosas, Shubhadeep Roychoudhury   +4 more
doaj   +1 more source

Stress Reduction, Bacterial Style [PDF]

Journal of Bacteriology, 2017
ABSTRACT Bacteria have robust responses to a variety of stresses. In particular, bacteria like Escherichia coli have multiple cell envelope stress responses, and generally we evaluate what these responses are doing by the repair systems they induce.
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

bridge between cell survival and cell death

EXCLI Journal : Experimental and Clinical Sciences, 2023
As a requirement of aerobic metabolism, regulation of redox homeostasis is indispensable for the continuity of living homeostasis and life. Since the stability of the redox state is necessary for the maintenance of the biological functions of the cells ...
Neşe Vardar Acar, Riza Köksal Özgül
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source