Results 51 to 60 of about 265,863 (294)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Neural scaling laws for an uncertain world [PDF]
, 2017 Autonomous neural systems must efficiently process information in a wide range of novel environments, which may have very different statistical properties. We consider the problem of how to optimally distribute receptors along a one-dimensional continuum
Howard, Marc W., Shankar, Karthik H.
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
AutomatikaThis paper presents a comparative study between intelligent and conventional control strategies for accurate 3D trajectory tracking with joint limit avoidance in spatial robotic manipulators.
Saumitra Kumar Kuri, M. Felix Orlando
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The impact of scatterometer wind data on global weather forecasting [PDF]
, 1984 The impact of SEASAT-A scatterometer (SASS) winds on coarse resolution atmospheric model forecasts was assessed. The scatterometer provides high resolution winds, but each wind can have up to four possible directions.
Atlas, D. +5 more
core +1 more source
A Phase Vocoder based on Nonstationary Gabor Frames
, 2016 We propose a new algorithm for time stretching music signals based on the theory of nonstationary Gabor frames (NSGFs). The algorithm extends the techniques of the classical phase vocoder (PV) by incorporating adaptive time-frequency (TF) representations
Dörfler, Monika, Ottosen, Emil Solsbæk
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Sensors, 2021 It is difficult to improve image resolution in hardware due to the limitations of technology and too high costs, but most application fields need high resolution images, so super-resolution technology has been produced. This paper mainly uses information
Shanshan Liu +3 more
doaj +1 more source