Results 181 to 190 of about 5,571,829 (332)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Genomic infrastructure for cetacean research and conservation: reference genomes for eight families spanning the cetacean tree of life

Frontiers in Marine Science
Reference genomes from representative species across families provide the critical infrastructure for research and conservation. The Cetacean Genomes Project (CGP) began in early 2020 to facilitate the generation of near error-free, chromosome-resolved ...
Phillip A. Morin, Bernhard Bein, Bernhard Bein, Chiara Bortoluzzi, Yury V. Bukhman, Taylor Hains, Taylor Hains, Dorothea Heimeier, Marcela Uliano-Silva, Marcela Uliano-Silva, Dominic E. Absolon, Linelle Abueg, Jessica Antosiewicz-Bourget, Jennifer R. Balacco, Robert K. Bonde, Nadolina Brajuka, Andrew C. Brownlow, Emma L. Carroll, Molly Carter, Joanna Collins, Nicholas J. Davison, Amy Denton, Olivier Fedrigo, Andrew D. Foote, Giulio Formenti, Guido R. Gallo, Carola Greve, Marlys L. Houck, Caroline Howard, Jeff K. Jacobsen, Nivesh Jain, Ksenia Krasheninnikova, Brigid M. Maloney, Bethan F. Manley, Thomas C. Mathers, Shane A. Mccarthy, Michael R. Mcgowen, Susanne Meyer, Jacquelyn Mountcastle, Benjamin A. Neely, Brian O’toole, Sarah Pelan, Patricia E. Rosel, Teri K. Rowles, Oliver A. Ryder, Tilman Schell, Ying Sims, Judy St Leger, Ron Stewart, Kerstin Ternes, Tatiana Tilley, Conor Whelan, Jonathan M. D. Wood, Michael Hiller, Michael Hiller, Mark Blaxter, Erich D. Jarvis, Erich D. Jarvis   +57 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The near-complete genome assembly of Ampelopsis grossedentata provides insights into its origin, evolution, and the regulation of flavonoid biosynthesis

Frontiers in Plant Science
Ampelopsis grossedentata, native to southern China, is renowned for its therapeutic and nutritional benefits, often called the “king of flavonoids” due to its high dihydromyricetin content.
Zhi Yao, Zhi Yao, Zhi Feng, Zhi Feng, Fuwen Wu, Fuwen Wu, Peiling Zhang, Peiling Zhang, Qiye Wang, Binling Ai, Yiqiang Wang, Yiqiang Wang, Meng Li, Meng Li   +13 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Whole Genome Sequences of the Wildtype AU-1 Rotavirus A Strain: The Prototype of the AU-1-like Genotype Constellation

Viruses
Most human rotaviruses belong to the Wa-like, DS-1-like, or AU-1-like genotype constellation. The AU-1-like constellation, albeit minor, captured attention because its prototype strain AU-1 originated from feline rotavirus, leading to the concept of ...
Chantal Ama Agbemabiese, Francis Ekow Dennis, Belinda Larteley Lartey, Susan Afua Damanka, Toyoko Nakagomi, Osamu Nakagomi, George Enyimah Armah   +6 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Sketched reference databases for genome-based taxonomy and comparative genomics

Brazilian Journal of Biology
Abstract The analysis of curated genomic, metagenomic and proteomic data is of paramount importance in the fields of biology, medicine, education, and bioinformatics. Although this type of data is usually hosted in raw format on free international repositories, the full access requires lots of computing power and large storage disk space for the ...
A. Sánchez-Reyes, M. G. Fernández-López   +1 more
openaire   +5 more sources