Results 81 to 90 of about 1,707,051 (309)

Specification of prior distributions under model uncertainty

, 2009
We consider the specification of prior distributions for Bayesian model comparison, focusing on regression-type models. We propose a particular joint specification of the prior distribution across models so that sensitivity of posterior model ...
Ntzoufras, Ioannis, Dellaportas, Petros, Forster, Jonathan J.   +2 more
core  

Reference-Based Multi-Lattice Indexing Method Integrating Prior Information in Free-Electron Laser Protein Crystallography

Applied Sciences
X-ray free-electron lasers (XFELs) have revolutionized structural biology by enabling “diffraction-before-destruction” and capturing the ultrafast dynamics of life.
Qi Wang, Zhi Geng, Zeng-Qiang Gao, Zhun She, Yu-Hui Dong   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A cautionary note on using the scale prior for the parameter N of a binomial distribution [PDF]

, 2014
Statistical analysis of ecological data may require the estimation of the size of a population, or of the number of species with a certain population. This task frequently reduces to estimating the discrete parameter N representing the number of trials ...
Villa, Cristiano
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Default Bayesian model determination methods for generalised linear mixed models

, 2010
In this paper, we consider a default strategy for fully Bayesian model determination for GLMMs. We address the two key issues of default prior specification and computation.
Overstall, Anthony M., Overstall, Antony, Forster, Jonathan, Overstall, Antony M., Forster, Jonathan J.   +4 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Connections between reference prior theory and global sensitivity analysis, an illustration with $f$-divergences

, 2023
International audienceThe reference prior theory constructs a framework which helps the resolution of the prior choice issue in Bayesian analysis, relying on the introduction of some information criteria called objective. Within the idea of a more global
Gauchy, Clément, Feau, Cyril, Van Biesbroeck, Antoine, Garnier, Josselin   +3 more
core   +2 more sources

Parametrizations and reference priors for multinomial decomposable graphical models

Journal of Multivariate Analysis, 2012
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Consonni, Guido, Massam, Helene
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source