Results 81 to 90 of about 157,821 (303)

Isogeometric B\'ezier dual mortaring: Refineable higher-order spline dual bases and weakly continuous geometry

, 2017
In this paper we develop the isogeometric B\'ezier dual mortar method. It is based on B\'ezier extraction and projection and is applicable to any spline space which can be represented in B\'ezier form (i.e., NURBS, T-splines, LR-splines, etc.).
Borden, M. J., Brivadis, E., Dornisch, W., Scott, M. A., Thomas, D. C., Zou, Z.   +5 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

On the use of finite strip method for buckling analysis of moderately thick plate by refined plate theory and using new types of functions

Latin American Journal of Solids and Structures
A numerical method is developed for the buckling analysis of moderately thick plate with different boundary conditions. The procedure use the finite strip method in conjunction with the refined plate theory (RPT).
Saeed Mirzaei, Mojtaba Azhari, Hossein Ali Rahimi Bondarabady   +2 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A multilayer anisotropic plate model with warping functions for the study of vibrations reformulated from Woodcock's work

, 2012
In this paper, a plate model suitable for static and dynamic analysis of inhomogeneous anisotropic multilayered plates is described. This model takes transverse shear variation through the thickness of the plate into account by means of warping functions
Castel, Alexis, Loredo, Alexandre
core   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Vibration Analysis of Laminated Composite Plates Carrying Rotating Circular Mass [PDF]

International Journal of Advanced Design and Manufacturing Technology, 2014
In this paper, the free vibration response of a laminated composite rectangularplate supporting a rotating circular patch mass is studied. The two variable refined platetheory that employs only two unknown functions as against three in the case of ...
Reza Alibakhshi, Reza Akbari Alashti
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A Virtual Element Method for 2D linear elastic fracture analysis

, 2018
This paper presents the Virtual Element Method (VEM) for the modeling of crack propagation in 2D within the context of linear elastic fracture mechanics (LEFM).
Nguyen-Thanh, Vien Minh, Nguyen-Xuan, Hung, Rabczuk, Timon, Wriggers, Peter, Zhuang, Xiaoying   +4 more
core   +1 more source

Linear and non-linear dynamic analyses of sandwich panels with face sheet-tocore debonding [PDF]

, 2020
А survey of recent developments in the dynamic analysis of sandwich panels with face sheet-to-core debonding is presented. The finite element method within the ABAQUSTM code is utilized.
Burlayenko, V. N., Sadowski, Tomasz
core