Results 71 to 80 of about 112,147 (264)

Refined BPS numbers on compact Calabi-Yau threefolds from Wilson loops

Journal of High Energy Physics
We relate the counting of refined BPS numbers on compact elliptically fibred Calabi-Yau threefolds X to Wilson loop expectations values in the gauge theories that emerge in various rigid local limits of the 5d supergravity theory defined by M-theory ...
Min-xin Huang, Sheldon Katz, Albrecht Klemm, Xin Wang   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Neutrosophication as a General Framework for Regret Theory, Grey System Theory, and Three-Way Decision Models

Neutrosophic Sets and Systems
Neutrosophy represents a comprehensive philosophical and mathematical framework for the study of neutrality, indeterminacy, and the interaction between opposites.
Florentin Smarandache
doaj   +1 more source

Analysis of the third-order structuring of Shalom Schwartz’s theory of basic human values

Heliyon, 2019
Shalom Schwartz's Theory of Basic Human Values is one of the most commonly used and tested transcultural theories in the field of behavioural research. This theory has been refined since the 1980s to reach its most recent version, from 2012.
August Corrons Giménez, Lluís Garay Tamajón   +1 more
doaj   +1 more source

Refining Theories of Change

Journal of MultiDisciplinary Evaluation, 2018
Background: Despite the disparities in how they are defined and what elements are included, most Theories of Change remain consistent in one way – their visual format. Typically, Theories of Change are presented as a one-page visual in a flowchart style with lines and boxes of uniform size.
Lovely Dhillon, Sara Vaca
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source