Results 111 to 120 of about 66,644 (298)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Noch einmal die peripherische Reflexion des Blutes
, 1892 NOCH EINMAL DIE PERIPHERISCHE REFLEXION DES BLUTES Noch einmal die peripherische Reflexion des Blutes (52) (-
Hoorweg, J. L.
core
Conquering Innovation in Telehealth
Blockchain in Healthcare Today, 2021 Session Description: The session covered how research and outcomes are linked to innovation presenting recent outcomes from a case use. Points of view from providers and innovators on patient care, science, and technology will be discussed. The ideation
Rajiv Leventhal (Moderator) +2 more
doaj
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Die diesjährige Ausgabe behandelt das Thema Reflexion. Reflexion ist ein wertvolles Werkzeug, das uns hilft, unser Denken, Handeln und Fühlen zu verstehen und zu vertiefen. In einer Welt, die von ständiger Veränderung und zunehmender Komplexität geprägt
core
Reflexion durch Forschendes Lernen? Analyse von Studienberichten
, 2018 Reflexion ist eines der zentralen Kennzeichen der Lehrerausbildung sowie ebenfalls Bestandteil professionellen Handelns im Berufsalltag von Lehrkräften.
Holler-Nowitzki, Birgit +5 more
core +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source