Results 111 to 120 of about 40,301 (251)

A Phantom Investigation of the Robustness and Adaptability of a Novel PET LINAC During Lung Cancer Biology-Guided Radiotherapy (BgRT) Characterized by Unplanned Perturbations in the Tumor Trajectory. [PDF]

Cancers (Basel)
Teboh R, Osunkwor O, Lewis B.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

[Chronic pain and persistent pain: A reflection from community-based practice]. [PDF]

Aten Primaria
Alcántara Montero A.
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

A Clinical Workflow for Evaluating Dose to Organs at Risk After Biology-Guided Radiation Therapy Delivery. [PDF]

Cancers (Basel)
Banks TI, Shen C, Godley AR, Park YK, Prasad R, Ravikiran M, Badiyan SN, Dan T, Garant A, Timmerman R, Jiang S, Cai B.   +11 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Evaluation of treatment planning feasibility of a positron emission tomography (PET)-Linac system for spine stereotactic body radiotherapy (SBRT). [PDF]

J Appl Clin Med Phys
Zhang H, Yan S, Peng H, Banks T, Prasad R, Park YK, Godley A, Cai B, Shen C.   +8 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Wahrnehmung als Reflexion [PDF]

Rechtsgeschichte - Legal History, 2002
Johannes-Michael Scholz
doaj   +1 more source

Chest wall heterotopic ossification causing restrictive physiology after resuscitative thoracotomy and surgical stabilization of rib fractures: a report and review. [PDF]

Trauma Surg Acute Care Open
Knight AW, Anderson M, Rahimy E, Forrester J.   +3 more
europepmc   +1 more source