Results 101 to 110 of about 191,226 (280)
, 2003 Die Schwierigkeit einer dialektischen Bestimmung der Reflexion gründet in dem Umstand, dass wir es mit einem Strukturbegriff des menschlichen Selbstverhältnisses, mit dem Ganzen des In-der-Welt-Seins zu tun haben und keineswegs mit einer transzendentalphilosophischen Begründung des Wissens.
openaire +3 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Knowledge Integration in Students After Transdisciplinary Communication with the Oldest Old [PDF]
Journal of Systemics, Cybernetics and InformaticsHow do students integrate their cognitive insights gained from dialogues with the oldest old persons? The lecture provides insight into an exploratory evaluation of self-reflexions written by students, which they prepared after an intergenerational ...
Sonja Ehret
doaj
Высшее образование в РоссииThe article analyzes the influence of training based on combined (combining asynchronous and synchronous forms in one pedagogical technology) online discussions (OD) on the formation of reflexion of future engineers.
S. A. Mikheev
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Noise in superconductor-quantum dot-normal metal structures in the Kondo regime
, 2009 We consider a N-dot-S junction in the Kondo regime in the limit where the superconducting gap is much smaller than the Kondo temperature. A generalization of the floating of the Kondo resonance is proposed and many body corrections to the average subgap ...
Crépieux, Adeline, Devillard, Pierre
core +1 more source