Results 121 to 130 of about 2,200,062 (357)

Swimming against the tide: a study of a neighbourhood trying to rediscover its ‘reason for being’– the case of South Bank, Redcar and Cleveland. [PDF]

, 2012
Many of the programmes and initiatives to regenerate deprived neighbourhoods appear to have had limited lasting impact. It has been argued that one reason for this is that we still have little real understanding of the nature and scale of the problems ...
Ashworth C, Bernt M, DTZ Pieda Consulting, Fuller C, Hildreth P, Instone P, Mah A, Nathaniel Litchfield and Partners, Pattinson G, Phillimore P, Redcar and Cleveland Borough Council, Redcar and Cleveland Borough Council, Redcar and Cleveland Borough Council, Robinson F, Robinson F, Schilling J, Schmuecker K, Somerville P   +17 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

KLF6 and STAT3 Co-Occupy Regulatory DNA and Functionally Synergize to Promote Axon Growth in CNS Neurons [PDF]

, 2018
The failure of axon regeneration in the CNS limits recovery from damage and disease. Members of the KLF family of transcription factors can exert both positive and negative effects on axon regeneration, but the underlying mechanisms are unclear.
Blackmore, Murray G., Eastwood, Dan C., Holan, Lyndsey, Maunze, Brian, Mehra, Vatsal, Simpson, Matthew T., Venkatesh, Ishwariya, Wang, Zimei   +7 more
core   +1 more source

Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate. [PDF]

, 2018
Pulmonary alveolar type I (AT1) cells cover more than 95% of alveolar surface and are essential for the air-blood barrier function of lungs. AT1 cells have been shown to retain developmental plasticity during alveolar regeneration.
Cai, Tao, Dai, Huaping, Huang, Huanwei, Li, Jiao, Li, Juan, Tang, Nan, Tang, Zan, Wang, Fengchao, Wang, Yanjie, Wang, Zheng, Yu, Yuanyuan, Zhang, Chengwei   +11 more
core   +1 more source

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor

Nature, 2018
Functional tissue regeneration is required for the restoration of normal organ homeostasis after severe injury. Some organs, such as the intestine, harbour active stem cells throughout homeostasis and regeneration; more quiescent organs, such as the lung,
W. Zacharias, D. Frank, Jarod A. Zepp, M. Morley, Farrah A. Alkhaleel, Jun Kong, Su Zhou, E. Cantu, E. Morrisey   +8 more
semanticscholar   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A sea of caesium: Atomically-standardized time and atomically-irradiated space in a nuclear Pacific

Regeneration
This article will develop the element caesium as both an organizing metaphor and a material trace that renders apprehensible the attritional violence of nuclear colonialism, a violence dispersed across time and space even as it is constitutive of a ...
Kaitlin T Moore
doaj   +2 more sources

'It'll get worse before it gets better': Local experiences of living in a regeneration area [PDF]

, 2013
The negative consequences of living in deprived neighbourhoods for residents’ quality of life are well documented. Area-based regeneration initiatives are invariably concerned with improving local quality of life over the long term.
Braidford, Paul, Davidson, Gill, Greenhalgh, Paul, McGuinness, David, Robinson, Fred   +4 more
core  

Determinants of postnatal spleen tissue regeneration and organogenesis [PDF]

, 2018
The spleen is an organ that filters the blood and is responsible for generating blood-borne immune responses. It is also an organ with a remarkable capacity to regenerate. Techniques for splenic auto-transplantation have emerged to take advantage of this
A Brendolan, A Futterer, A Sabatino Di, A Tumanov, A Yamataka, CL Zindl, DR Withers, E Dejardin, F Weih, G Eberl, I Carlo Di, I Miko, J Westermann, JJ Koning, JK Tan, JK Tan, K Honda, K Hoorweg, KF Kovacs, KU Willfuhr, L Castagnaro, L Onder, MF Vondenhoff, MY Kim, NW Gale, P Togni De, R Pabst, RD Fremont, RE Mebius, RE Mebius, RJ Holdsworth, SH Glanville, T Cupedo, T Cupedo, T Katakai, TA Banks, VN Ngo, WR Pan, Z Sun   +38 more
core   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source