Results 81 to 90 of about 1,641,482 (341)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Virtual regeneration [PDF]

, 1998
Regenerating our increasingly polluted, worn-out urban infrastructure is becoming the singly most important challenge facing our cities. Simon Doyle and Michael Batty explain how spatial information technologies and online laboratories can enable many ...
Batty, M, Doyle, S
core  

Swimming against the tide: a study of a neighbourhood trying to rediscover its ‘reason for being’– the case of South Bank, Redcar and Cleveland. [PDF]

, 2012
Many of the programmes and initiatives to regenerate deprived neighbourhoods appear to have had limited lasting impact. It has been argued that one reason for this is that we still have little real understanding of the nature and scale of the problems ...
Ashworth C, Bernt M, DTZ Pieda Consulting, Fuller C, Hildreth P, Instone P, Mah A, Nathaniel Litchfield and Partners, Pattinson G, Phillimore P, Redcar and Cleveland Borough Council, Redcar and Cleveland Borough Council, Redcar and Cleveland Borough Council, Robinson F, Robinson F, Schilling J, Schmuecker K, Somerville P   +17 more
core   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Global Responses of Il-1β-Primed 3D Tendon Constructs to Treatment with Pulsed Electromagnetic Fields

Cells, 2019
Tendinopathy is accompanied by a cascade of inflammatory events promoting tendon degeneration. Among various cytokines, interleukin-1β plays a central role in driving catabolic processes, ultimately resulting in the activation of matrix ...
Renate Gehwolf, Bettina Schwemberger, Malik Jessen, Stefanie Korntner, Andrea Wagner, Christine Lehner, Nadja Weissenbacher, Herbert Tempfer, Andreas Traweger   +8 more
doaj   +1 more source

Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate. [PDF]

, 2018
Pulmonary alveolar type I (AT1) cells cover more than 95% of alveolar surface and are essential for the air-blood barrier function of lungs. AT1 cells have been shown to retain developmental plasticity during alveolar regeneration.
Cai, Tao, Dai, Huaping, Huang, Huanwei, Li, Jiao, Li, Juan, Tang, Nan, Tang, Zan, Wang, Fengchao, Wang, Yanjie, Wang, Zheng, Yu, Yuanyuan, Zhang, Chengwei   +11 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Synergistic effect of umbilical cord extracellular vesicles and rhBMP-2 to enhance the regeneration of a metaphyseal femoral defect in osteoporotic rats

Stem Cell Research & Therapy
Background The aim of this study was to evaluate potential synergistic effects of a single, local application of human umbilical cord MSC-derived sEVs in combination with a low dose of recombinant human rhBMP-2 to promote the regeneration of a ...
Amelie Deluca, Andrea Wagner, Patrick Heimel, Christian Deininger, Florian Wichlas, Heinz Redl, Eva Rohde, Herbert Tempfer, Mario Gimona, Andreas Traweger   +9 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Viral Vector-based Improvement of Optic Nerve Regeneration: Characterization of Individual Axons\u27 Growth Patterns and Synaptogenesis in a Visual Target [PDF]

, 2015
Lack of axon growth ability in the central nervous system poses a major barrier to achieving functional connectivity after injury. Thus, a non-transgenic regenerative approach to reinnervating targets has important implications in clinical and research ...
Blackmore, Murray G., Luo, Xueting, Salgueiro, Yadira, Yungher, Benjamin J.   +3 more
core   +1 more source