Results 41 to 50 of about 22,352 (301)

An Ultra-Compact X-ray Regenerative Amplifier Free-Electron Laser

Instruments
There is a growing interest in designing and building compact X-ray Free Electron Lasers (FELs) for scientific and industry applications. In this paper, we report an X-ray Regenerative Amplifier FEL (XRAFEL) design based on a proposed Ultra Compact X-ray
Madison Singleton, James Rosenzweig, Jingyi Tang, Zhirong Huang   +3 more
doaj   +1 more source

Time-dependent photoionization of azulene: Competition between ionization and relaxation in highly excited states [PDF]

, 2008
Pump-probe photoionization has been used to map the relaxation processes taking place from highly vibrationally excited levels of the S2 state of azulene, populated directly or via internal conversion from the S4 state.
Blanchet, V., Chatel, B., Garcia, I.A., Girard, B., Raffael, K., Turri, G., Whitaker, B.J., Wilkinson, I.   +7 more
core   +6 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Noise auto-correlation spectroscopy with coherent Raman scattering

, 2007
Ultrafast lasers have become one of the most powerful tools in coherent nonlinear optical spectroscopy. Short pulses enable direct observation of fast molecular dynamics, whereas broad spectral bandwidth offers ways of controlling nonlinear optical ...
AM Weiner, AM Zheltikov, B von Vacano, CHR Ooi, D Meshulach, D Oron, D Oron, D Pestov, HP Lu, IS Averbukh, John W. Hepburn, JX Cheng, JX Cheng, M Schmitt, M Shapiro, MJ Stimson, MJ Stimson, MO Scully, N Dudovich, O Kinrot, S-H Lim, Stanislav O. Konorov, T Lang, T Rom, Valery Milner, W Schrof, XG Xu, Xiaoji G. Xu, Y Paskover   +28 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

50 nm GaAs mHEMTs and MMICs for ultra-low power distributed sensor network applications [PDF]

, 2006
We report well-scaled 50 nm GaAs metamorphic HEMTs (mHEMTs) with DC power consumption in the range 1-150 ΜW/Μ demonstrating f_T of 30-400 GHz.
Elgaid, K., Holland, M., McLelland, H., Moran, D.A.J., Stanley, C., Thayne, I., Thoms, S.   +6 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

12-mJ 1-kHz cryogenically cooled rod Yb:YAG regenerative amplifier

Frontiers in Physics
We report on a continuous-wave (CW) pumped cryogenically cooled rod Yb:YAG regenerative amplifier delivering uncompressed 12-mJ, 90-ps, 1030-nm pulses at a 1-kHz repetition rate. The amplifier demonstrates an efficiency of 31.7%.
Guangyin Zhang, Guangyin Zhang, Ruixuan Li, Ruixuan Li, Kui Li, Kui Li, Jie Li, Zhenao Bai, Zhongwei Fan   +8 more
doaj   +1 more source

Generation of tunable subpicosecond light pulses in the midinfrared between 4.5 and 11.5 Mum [PDF]

, 1993
Stable subpicosecond infrared pulses in the spectral region of 4.5-11.5 ,um are generated by difference-frequency mixing in AgGaS2. The system uses femtosecond pulses from a Ti:sapphire regenerative amplifier and from a tunable traveling-wave dye laser ...
Hamm, P., Lauterwasser, Christoph, Zinth, Wolfgang   +2 more
core