Results 61 to 70 of about 277,643 (298)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A Sub-Picosecond Laser System Based on High-Energy Yb:YAG Chirped-Pulse Regenerative Amplification

Photonics
In this study, we have successfully demonstrated a high-energy subpicosecond Yb:YAG laser system based on chirped-pulse regenerative amplification.
Minjian Wu, Yixing Geng, Dahui Wang, Yanying Zhao   +3 more
doaj   +1 more source

Development of high-energy fiber CPA system

EPJ Web of Conferences, 2013
An intense broadband laser system based on a Nd:glass chirped pulse amplifier (CPA) requires a stable front end with good beam quality. To prepare such a front end without using a regenerative amplifier or optical parametric chirped pulse amplification ...
Ogino J., Sueda K., Kurita T., Kawashima T., Miyanaga N.   +4 more
doaj   +1 more source

Acute Endocrine Alterations After Traumatic Brain Injury and 6‐Month Functional Outcome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Acute multi‐axis endocrine alterations after traumatic brain injury (TBI) remain incompletely characterized. This study aimed to examine their temporal patterns and explore their associations with 6‐month functional outcome and early inflammatory markers.
Biao Xu, Peng Guo, Rui Pan, Zhenghao Wang, Jingchao Zhou, Pengcheng Zhang, Xingzhe Zhang, Qinghua Zhang, Haibin Ma, Zhanfeng Niu   +9 more
wiley   +1 more source

Three-dimensional, time-dependent simulation of a regenerative amplifier free-electron laser

Physical Review Special Topics. Accelerators and Beams, 2013
Free-electron lasers have been designed to operate over virtually the entire electromagnetic spectrum from microwaves through x rays and in a variety of configurations including amplifiers and oscillators.
H. P. Freund, D. C. Nguyen, P. A. Sprangle, P. J. M. van der Slot   +3 more
doaj   +1 more source

Advances in Sustainable and Wearable Textile Based Soft Robotics

Advanced Functional Materials, EarlyView.
This Review examines advances in wearable textile‐based soft robotics, focusing on sustainable materials, integrated sensing, and scalable actuation. It discusses manufacturing and system integration across healthcare, assistive robotics, prosthetics, and human–machine interfaces, and highlights key challenges in circular design, including life‐cycle ...
Zahir Abbas, Marzia Dulal, Sophia K. Novoselov, Victoria K. Novoselov, Kostya S. Novoselov, Shaila Afroj, Nazmul Karim   +6 more
wiley   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Directly diode-pumped Yb3+:SrY4(SiO4)3O regenerative amplifier

, 2003
International audienceWe report a regenerative amplifier based on an Yb-doped apatite crystal: Yb31:SrY4_SiO4_3O (Yb:SYS). We obtained 420-fs pulses at a central wavelength of 1066 nm with an energy of 100 mJ at 300 Hz after compression.
Balembois, François, Druon, Frédéric, Raybaut, Pierre, Gaume, Romain, Georges, Patrick, Viana, Bruno, Vivien, Daniel   +6 more
core   +1 more source

Dynamics of high repetition rate regenerative amplifiers

Optics Express, 2007
Dynamics features of high repetition rate continuously pumped solid-state regenerative amplifiers were studied numerically. A space independent rate equations and discrete-time dynamical system approach were used for system state evolution analysis. Regular single-energy operation, quasi-periodic pulsing and chaotic behavior regions are distinguished ...
M, Grishin, V, Gulbinas, A, Michailovas
openaire   +2 more sources