Results 41 to 50 of about 7,235 (262)

Development of high-energy fiber CPA system

EPJ Web of Conferences, 2013
An intense broadband laser system based on a Nd:glass chirped pulse amplifier (CPA) requires a stable front end with good beam quality. To prepare such a front end without using a regenerative amplifier or optical parametric chirped pulse amplification ...
Ogino J., Sueda K., Kurita T., Kawashima T., Miyanaga N.   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Regenerative Nd:glass amplifier seeded with a Nd:fiber laser [PDF]

Optics Letters, 1992
Wavelength tuning and broad-bandwidth operation of a passively mode-locked Nd:fiber laser is demonstrated at 1060 microm. The oscillator pulses are used to seed a bulk regenerative Nd:glass amplifier, and 300-fs transformlimited pulses with an energy of 10 microJ are obtained after 31 round trips at a repetition rate of 500 Hz.
Hofer, M., Ober, M.H., Haberl, F., Fermann, M.E., Taylor, E.R., Jedrzejewski, K.P.   +5 more
openaire   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

An x-ray regenerative amplifier free-electron laser using diamond pinhole mirrors

New Journal of Physics, 2019
X-ray free-electron lasers (FELs) rely on SASE due to the lack of seed lasers and the difficulty in obtaining mirrors. Progress in diamond crystal Bragg mirrors enables the design of x-ray FEL oscillators.
H P Freund, P J M van der Slot, Yu Shvyd’ko   +2 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

A Sub-Picosecond Laser System Based on High-Energy Yb:YAG Chirped-Pulse Regenerative Amplification

Photonics
In this study, we have successfully demonstrated a high-energy subpicosecond Yb:YAG laser system based on chirped-pulse regenerative amplification.
Minjian Wu, Yixing Geng, Dahui Wang, Yanying Zhao   +3 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source