Results 41 to 50 of about 277,643 (298)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

An Ultra-Compact X-ray Regenerative Amplifier Free-Electron Laser

Instruments
There is a growing interest in designing and building compact X-ray Free Electron Lasers (FELs) for scientific and industry applications. In this paper, we report an X-ray Regenerative Amplifier FEL (XRAFEL) design based on a proposed Ultra Compact X-ray
Madison Singleton, James Rosenzweig, Jingyi Tang, Zhirong Huang   +3 more
doaj   +1 more source

A rail‐to‐rail regenerative comparator with inverse inverter pre‐amplifier for low supply voltage applications

Electronics Letters, 2023
In this letter, a new rail‐to‐rail two‐stage regenerative comparator for low supply voltage applications is presented. A rail‐to‐rail operation is achieved by utilizing an inverse inverter pre‐amplifier.
Hadi Pahlavanzadeh, Saba Iesakhani, Mohammad Azim Karami   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Amplification of 1 ps pulses at 1.053 [mu]m in a Ti:Al2O3 regenerative amplifier [PDF]

, 1991
We demonstrate the operation of a Ti:Al2O3 regenerative amplifier tunable around 1 [mu]m. Gains up to 108 at 1.053 [mu]m without any spectral narrowing are obtained.
Mourou, Gerard A., Rouyer, Claude, Salin, Francois, Squier, Jeff, Coe, Scott   +4 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Ultra-stable, diode-pumped Nd-doped glass regenerative amplifier for the National Ignition Facility (NIF) [PDF]

, 1995
We describe a diode laser-pumped Nd:glass regenerative amplifier that amplifies temporally shaped pulses with low distortion, high pulse-to- pulse stability, and high gain. This laser amplifier is a prototype subsystem for the National Ignition Facility (
Pratt, G., Christensen, J.J., Crane, J.K., Mitchell, S., Martinez, M., Beach, R.J.   +5 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

12-mJ 1-kHz cryogenically cooled rod Yb:YAG regenerative amplifier

Frontiers in Physics
We report on a continuous-wave (CW) pumped cryogenically cooled rod Yb:YAG regenerative amplifier delivering uncompressed 12-mJ, 90-ps, 1030-nm pulses at a 1-kHz repetition rate. The amplifier demonstrates an efficiency of 31.7%.
Guangyin Zhang, Guangyin Zhang, Ruixuan Li, Ruixuan Li, Kui Li, Kui Li, Jie Li, Zhenao Bai, Zhongwei Fan   +8 more
doaj   +1 more source