Results 41 to 50 of about 7,649 (264)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Development of high-energy fiber CPA system

EPJ Web of Conferences, 2013
An intense broadband laser system based on a Nd:glass chirped pulse amplifier (CPA) requires a stable front end with good beam quality. To prepare such a front end without using a regenerative amplifier or optical parametric chirped pulse amplification ...
Ogino J., Sueda K., Kurita T., Kawashima T., Miyanaga N.   +4 more
doaj   +1 more source

Regenerative Nd:glass amplifier seeded with a Nd:fiber laser [PDF]

Optics Letters, 1992
Wavelength tuning and broad-bandwidth operation of a passively mode-locked Nd:fiber laser is demonstrated at 1060 microm. The oscillator pulses are used to seed a bulk regenerative Nd:glass amplifier, and 300-fs transformlimited pulses with an energy of 10 microJ are obtained after 31 round trips at a repetition rate of 500 Hz.
Hofer, M., Ober, M.H., Haberl, F., Fermann, M.E., Taylor, E.R., Jedrzejewski, K.P.   +5 more
openaire   +3 more sources

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

An x-ray regenerative amplifier free-electron laser using diamond pinhole mirrors

New Journal of Physics, 2019
X-ray free-electron lasers (FELs) rely on SASE due to the lack of seed lasers and the difficulty in obtaining mirrors. Progress in diamond crystal Bragg mirrors enables the design of x-ray FEL oscillators.
H P Freund, P J M van der Slot, Yu Shvyd’ko   +2 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A Sub-Picosecond Laser System Based on High-Energy Yb:YAG Chirped-Pulse Regenerative Amplification

Photonics
In this study, we have successfully demonstrated a high-energy subpicosecond Yb:YAG laser system based on chirped-pulse regenerative amplification.
Minjian Wu, Yixing Geng, Dahui Wang, Yanying Zhao   +3 more
doaj   +1 more source

Adaptive Foam 3D Printing of Ultralight and Multifunctional Materials

Advanced Engineering Materials, EarlyView.
Adaptive foam 3D printing, enabled by expandable microspheres, imparts cellular structures to thermoplastic and thermosetting polymers, manufactured through a variety of processes including fused filament fabrication, direct ink writing, digital light processing, and inkjet printing.
Nariman Rajabifar, Amir Ameli
wiley   +1 more source

Three-dimensional, time-dependent simulation of a regenerative amplifier free-electron laser

Physical Review Special Topics. Accelerators and Beams, 2013
Free-electron lasers have been designed to operate over virtually the entire electromagnetic spectrum from microwaves through x rays and in a variety of configurations including amplifiers and oscillators.
H. P. Freund, D. C. Nguyen, P. A. Sprangle, P. J. M. van der Slot   +3 more
doaj   +1 more source