Results 61 to 70 of about 22,352 (301)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Simulation of a Regenerative MW FEL Amplifier [PDF]

open access: yes, 1998
Both oscillator and regenerative amplifier configurations are being studied to optimize the design of a MW-class FEL. The regenerative amplifier uses a longer undulator and relies on higher extraction efficiency to achieve high average power, whereas the oscillator is a more compact overall design requiring the transport of the high energy electron ...
Nguyen, R. T.   +3 more
openaire   +3 more sources

Optical Fiber Pumped High Repetition Rate and High Power Nd:YVO4 Picosecond Regenerative Amplifier

open access: yesApplied Sciences, 2015
We report a stable optical fiber pumped Nd:YVO4 all solid state regenerative amplifier with all fiber picosecond laser as seed source. 888 nm Yb optical fiber lasers was chosen as pump source to reduce quantum defect for improved thermal performance.
Zhen-Ao Bai   +5 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Regulated dc to dc converter [PDF]

open access: yes, 1969
Regulated dc to dc ...
Thornwall, J. C.
core   +1 more source

Femtosecond response time measurements of a Cs2Te photocathode

open access: yes, 2017
We present the response time measurements of a Cs2Te photocathode illuminated with two 100 fs duration, variable time separation laser pulses at 266 nm wavelength. The response time was confirmed in dispersive region downstream of a 12-cell standing wave
Aryshev, A.   +4 more
core   +1 more source

A direct-sequence spread-spectrum super-regenerative receiver [PDF]

open access: yes, 2000
Current applications of the super-regenerative receiver use narrowband modulations. In this paper a new architecture that allows incoherent detection of spread-spectrum signals is presented.
Mas Casals, Orestes Miquel   +2 more
core   +1 more source

Harnessing Fungal Biowelding for Constructing Mycelium‐Engineered Materials

open access: yesAdvanced Engineering Materials, EarlyView.
Mycelium‐bound composites (MBCs) offer low‐carbon alternatives for construction, yet interfacial bonding remains a critical challenge. This review examines fungal biowelding as a biocompatible adhesive, elucidating mycelium‐mediated interfacial mechanisms and their role in material assembly. Strategies to optimize biowelding are discussed, highlighting
Xue Brenda Bai   +2 more
wiley   +1 more source

A Sub-Picosecond Laser System Based on High-Energy Yb:YAG Chirped-Pulse Regenerative Amplification

open access: yesPhotonics
In this study, we have successfully demonstrated a high-energy subpicosecond Yb:YAG laser system based on chirped-pulse regenerative amplification.
Minjian Wu   +3 more
doaj   +1 more source

Three-dimensional, time-dependent simulation of a regenerative amplifier free-electron laser

open access: yesPhysical Review Special Topics. Accelerators and Beams, 2013
Free-electron lasers have been designed to operate over virtually the entire electromagnetic spectrum from microwaves through x rays and in a variety of configurations including amplifiers and oscillators.
H. P. Freund   +3 more
doaj   +1 more source

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