Results 71 to 80 of about 203,031 (265)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Spinal Cord Cells from Pre-metamorphic Stages Differentiate into Neurons and Promote Axon Growth and Regeneration after Transplantation into the Injured Spinal Cord of Non-regenerative Xenopus laevis Froglets

Frontiers in Cellular Neuroscience, 2017
Mammals are unable to regenerate its spinal cord after a lesion, meanwhile, anuran amphibians are capable of spinal cord regeneration only as larvae, and during metamorphosis, this capability is lost.
Emilio E. Méndez-Olivos, Rosana Muñoz, Juan Larraín   +2 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Effect of regenerative effectiveness on the performance of simple gas turbine

Scientia Africana
The deregulation of the power and energy sector introduced a strong element of competition. Power plant operators try to develop techniques to maximize profits in the dynamic power industry. New methods of improving and optimizing simple gas turbine power plants are needed to enhance operational decision making and therefore to maximize power plant ...
Ogbe, E.E., Ossia, C.V., Saturday, E., Ezekwem, C.   +3 more
openaire   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Synergizing adaptive immunity and regenerative signals to enhance osteochondral defects repair

Bioactive Materials
In clinical practice, repairing osteochondral defects (OCDs) is challenging because of the complex cartilage/subchondral bone structure and intricate immunological microenvironment.
Changjian Lin, Chenting Ying, Yibo Xu, Yuxuan Zou, Ruihan Chen, Kaicheng Xu, Xiaoxiao Ji, Qihua Cao, Jiahui Weng, Lifeng Jiang, Chenyi Ye, Kai Xu, Yuzhe He, Weijun Li, Lidong Wu, Jisheng Ran, Yan Xiong, Xiaohua Yu, Jiapeng Bao   +18 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Regenerative braking energy efficient synergistic utilization technology for AC electrified railways

机车电传动, 2022
Strengthening the research and application of regenerative braking energy utilization technology is an important measure to promote the low carbon development of AC electrified railways.
LYU Shunkai, ZHANG Min, ZHANG Zhixue
doaj  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Regenerative agriculture: connecting soil carbon storage, biodiversity, and profit

Environmental Research: Food Systems
Amidst alternative carbon capture and storage strategies (Küng 2023 Energy Environ. Sci. 16 4280; Dupla et al 2024 Sci. Total Environ. 954 176297), regenerative agriculture seeks to attain climate mitigation goals while simultaneously reducing ecosystem ...
Jonathan G Lundgren, Kelton D Welch, Michael M Bredeson, Katya Busenitz, Robin Buterbaugh, Thomas L D Fenster, Kent C Jensen, Daniel Pecenka, Ryan B Schmid   +8 more
doaj   +1 more source