Results 81 to 90 of about 3,835,856 (260)

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

The Role of Microenvironment Stromal Cells in Regenerative Medicine

, 2010
Regenerative medicines offer the potential for treatment and possibly cure of debilitating diseases including heart disease, diabetes, Parkinson’s disease and liver failure.
Hare, Joshua, Joshua Hare, Ian McNiece, McNiece, Ian   +3 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Advanced Tools of Regenerative Medicine for Neurodegenerative Diseases

, 2012
The goal of regenerative medicine for neurodegenerative diseases is the design of a patient-specific therapeutic approach. A plethora of patents promoting innovative therapeutic tools will contribute to this ambitious purpose.
D'Angelo F., MARTINO, Sabata, TIRIBUZI, ROBERTO, ORLACCHIO, Aldo   +3 more
core  

Quo vadis regenerative medicine? [PDF]

, 2013
There are presented the most important sources of pluripotent stem cells for potential application in the regenerative medicine. This review summarizes also the advantages and disadvantages for potential application of these cells in clinical ...
Suszyńska, Malwina; Katedra i Zakład Fizjologii Pomorskiego Uniwersytetu Medycznego, Kierownik: prof. dr hab. n. med. Mariusz Z. Ratajczak, Szczecin, Polska; Stem Cell Institute at James Graham Brown Cancer Center University of Louisville, Louisville, Kentucky, USA, Ratajczak, Mariusz Z.; Katedra i Zakład Fizjologii Pomorskiego Uniwersytetu Medycznego, Kierownik: prof. dr hab. n. med. Mariusz Z. Ratajczak, Szczecin, Polska; Stem Cell Institute at James Graham Brown Cancer Center University of Louisville, Louisville, Kentucky, USA   +1 more
core   +1 more source

Regenerative Medicine for Diabetes Mellitus

Cell Transplantation, 2009
In diabetes, a loss of pancreatic β-cells causes insulin dependency. When insulin dependency is caused by type 1 diabetes or pancreatic diabetes, for example, pancreatic β-cells need to be regenerated for definitive treatment.
Naoya Kobayashi M.D., Ph.D., Takeshi Yuasa, Teru Okitsu   +2 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Engineered Microenvironments for 3D Cell Culture and Regenerative Medicine: Challenges, Advances, and Trends

, 2022
The overall goal of regenerative medicine is to restore the functional performance of the tissues and organs that have been severely damaged or lost due to traumas and diseases [...
Anna Guller, Alexandra Igrunkova, Guller, A ; https://orcid.org/, Igrunkova, A   +3 more
core   +1 more source

Regenerative medicine in cardiovascular disease

Regenerative Therapy
Owing to the rapid increase in the number of people with severe heart failure, regenerative medicine is anticipated to play a role in overcoming the limitations inherent in existing surgical interventions.
Takasumi Goto, Yuki Nakamura, Yoshito Ito, Shigeru Miyagawa   +3 more
doaj   +1 more source