Results 91 to 100 of about 14,577,864 (375)
Social Capital and Economic Well-Being in Germany's Regions: An Exploratory Spatial Analysis
REGION, 2016 This article explores social capital in Germany in line with Putnam’s claim that social capital benefits regional economic well-being. In particular, this macro-level study examines whether the number of civic associations, as a measure of a vibrant ...
Katrin Botzen
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FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
REGION, 2016 Pride in one’s city is an individual, and collective as well as institutional response to urban conditions which may be harnessed in support of expanding urban facilities and services.
Philip S Morrison
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Architecture and the Built Environment, 2017 In recent decades the Netherlands has seen an increase in the use of regional design-led practices in national indicative planning. Despite this, the interrelations between design and planning decision making are not well understood and attempts to involve the expertise and ambition of designers in planning have had unclear outcomes.
openaire +6 more sources
REGIONAL DISPARITIES IN CANADA: INTERPROVINCIAL OR URBAN/RURAL? [PDF]
The nature of regional disparities in Canada is analysed in this paper, with a focus on their interprovincial or urban/rural nature. Starting by presenting a traditional approach to regional disparities in Canada, we show that statistics indeed lead us ...
Pierre-Marcel DESJARDINS
core
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
CHARACTER CHANGES CAUSED BY MUTATION OF AN ENTIRE REGION OF A CHROMOSOME IN DROSOPHILA [PDF]
, 1919 Otto L. Mohr
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META-ANALYSIS OF EMPIRICAL EVIDENCE ON THE LABOUR MARKET IMPACTS OF IMMIGRATION [PDF]
The increasing proportion of immigrants in the population of many countries has raised concerns about the ‘absorption capacity’ of the labour market, and fuelled extensive empirical research in countries that attract migrants.
Jacques POOT +2 more
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Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Functional Labour Market Areas for Chile
REGION, 2017 Administrative areas are arbitrarily designed and do not necessarily reflect the geographical patterns of socio-economic and labour market activity. Labour market areas (LMAs) are required to analyse spatial labour market activity and provide a framework
Francisco Rowe
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