Results 81 to 90 of about 14,433,678 (306)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
REGION, 2016 Pride in one’s city is an individual, and collective as well as institutional response to urban conditions which may be harnessed in support of expanding urban facilities and services.
Philip S Morrison
doaj +1 more source
META-ANALYSIS OF EMPIRICAL EVIDENCE ON THE LABOUR MARKET IMPACTS OF IMMIGRATION [PDF]
The increasing proportion of immigrants in the population of many countries has raised concerns about the ‘absorption capacity’ of the labour market, and fuelled extensive empirical research in countries that attract migrants.
Jacques POOT +2 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Juan Manuel Barragán Muñoz [PDF]
Revista de Estudios Andaluces, 1986 Aportación al estudio de la región portuaria andaluza
doaj +1 more source
FUNDAMENTAL ECONOMIC STRUCTURE AND STRUCTURAL CHANGE IN REGIONAL ECONOMIES: A METHODOLOGICAL APPROACH [PDF]
Regional economic structure is defined as the composition and patterns of various components of the regional economy such as: produc-tion, employment, consumption, trade, and gross regional product.
Sudhir K. THAKUR
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
SPATIAL-COMPETITION, INTEGRATED FRAMEWORK OF CENTRAL-PLACE SYSTEM WITH AGGLOMERATION ECONOMIES [PDF]
It is argued that the trade-off interaction between agglomeration economies and transportation costs cannot be excluded from the analysis of the central-place system.
Daisuke NAKAMURA
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source