Tailoring Regioselectivity‐Controlled UDP‐Glycosyltransferase for Bidirectional Glycosylation of Tyrosol via Free Energy‐Driven Pocket Reshaping and Tunnel Engineering [PDF]
Advanced ScienceUDP‐glycosyltransferases (UGTs) are pivotal biocatalysts for synthesizing pharmaceutically valuable active components; however, their application is frequently constrained by poor regioselectivity and suboptimal catalytic efficiency.
Ziyu Zhang +7 more
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Regioselectivity Study of Contrasteric Aromatic Claisen Rearrangements and Their Utilization in the Total Syntheses of 5-Hydroxymellein and Botyroisocoumarin A. [PDF]
J Org ChemTanas DK +14 more
europepmc +2 more sources
Understanding a substrate's product regioselectivity in a family of enzymes: a case study of acetaminophen binding in cytochrome P450s. [PDF]
PLoS ONE, 2014 Product regioselectivity as influenced by molecular recognition is a key aspect of enzyme catalysis. We applied large-scale two-dimensional (2D) umbrella sampling (USP) simulations to characterize acetaminophen (APAP) binding in the active sites of the ...
Yue Yang +2 more
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Regioselectivity of conjugate additions to monoalkyl-1,4-benzoquinones [PDF]
Journal of the Serbian Chemical Society, 2002 The regioselectivity of the reaction of conjugate addition of thiols amines, methanol and hydrogen chloride with the monoalkyl-1,4-benzoquinones avarone and 2-tert-butyl- 1,4-benzoquinone was investigated.
Božić Tatjana T. +5 more
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Scientific Reports, 2021 Enzymes with low regioselectivity of substrate reaction sites may produce multiple products from a single substrate. When a target product is produced industrially using these enzymes, the production of non-target products (byproducts) causes adverse ...
Jinzen Ikebe +4 more
doaj +1 more source
Highly efficient and enzymatic regioselective undecylenoylation of gastrodin in 2-methyltetrahydrofuran-containing systems. [PDF]
PLoS ONE, 2014 Highly efficient and regioselective acylation of pharmacologically interesting gastrodin with vinyl undecylenic acid has been firstly performed through an enzymatic approach. The highest catalytic activity and regioselectivity towards the acylation of 7'-
Rongling Yang +5 more
doaj +1 more source
Regioselective conversion of epoxides to β-acetoxy alcohols catalyzed by a novel green and recyclable phase transfer catalyst [PDF]
شیمی کاربردی روز, 2018 A new mild and efficient procedure for the ring opening of epoxides by acetate anion in the presence of catalytic amounts of silica-bound polyethylene glycol substituted 1-methylimidazolium bromide, SiO2-PEG-ImBr, as an effective heterogeneous phase ...
ندا عیاشی +2 more
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Molecules, 2021 A series of novel 4-(het)arylimidazoldin-2-ones were obtained by the acid-catalyzed reaction of (2,2-diethoxyethyl)ureas with aromatic and heterocyclic C-nucleophiles.
Almir S. Gazizov +10 more
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An efficient synthesis of novel triazoles incorporating barbituric motifs via [3+2] cycloaddition reaction: An experimental and theoretical study [PDF]
Journal of the Serbian Chemical Society, 2018 In this work, the synthesis of novel triazole derivatives with barbituric motifs in good yields is described. The alkyne was prepared through the Knoevenagel reaction of barbituric derivatives with ortho and para O-propargylated hydroxybenzaldehyde.
Darroudi Mahdieh +2 more
doaj +1 more source
Comptes Rendus. Chimie, 2022 The regioselectivity of molecular sieves-promoted oxidative three-component reaction between $\beta $-ketoesters, aromatic o-diamines and acrolein, leading to pyrido[1,2-a]benzimidazoles, has been investigated by a combination of experimental and ...
Martin, Anthony +8 more
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