Results 41 to 50 of about 37,566 (244)

Regioselectivity-Switchable Catalytic Annulations of Alkynyl α‑Diketones and α‑Cyanoketones

, 2019
Regioselectivity-switchable reactions hold irreplaceable importance in the construction of diversified architectures. In this work, Brønsted base-catalyzed regioselectivity-switchable annulations between alkynyl α-diketones and α-cyanoketones have been ...
Xinqiang Fang, Rui Liu, Banoth Paplal, Rui Liu (54031), Shuhua Liu (1598038), Jinggong Liu, Jinggong Liu (1528981), Shuang Yang (64650), Zhizhou Chen, Banoth Paplal (8072522), Shuang Yang, Sakkani Nagaraju, Shuhua Liu, Zhizhou Chen (8072519), Xinqiang Fang (1904908), Sakkani Nagaraju (8072516)   +15 more
core   +1 more source

Electron Donor–Acceptor Complex Catalysis in Synthetic Chemistry

Angewandte Chemie, EarlyView.
Electron donor–acceptor (EDA) complexes are moving beyond stoichiometric photoactivation toward catalytic platforms for radical generation. Productive EDA catalysis requires coordinated donor–acceptor association, charge‐transfer excitation, radical reactivity, and vcatalyst turnover.
Tristan von Münchow, Andrea Palone, Jonathan Samuel Trimble, Paolo Melchiorre   +3 more
wiley   +2 more sources

Improving regioselectivity of phenylalanine aminomutase from Taxus chinensis by semi-rational mutagenesis for the biocatalytic amination of cinnamates

Frontiers in Bioengineering and Biotechnology
The occupancy of the binding pocket by the substrate ultimately determines the outcome of enzyme catalysis. Previous engineering and substrate scope of phenylalanine aminomutase from Taxus chinensis (TcPAM) has generated valuable knowledge about the ...
Tao Tang, Miao Wang, Yunyun Zhang, Yijun Chen   +3 more
doaj   +1 more source

Ping–Pong Energy Transfer in a Heteroleptic Mixed‐Chromophore Coordination Cage

Angewandte Chemie, EarlyView.
Shape‐complementary assembly (SCA) opens access to Pd(II)‐based heteroleptic cages with mixed‐chromophore composition. Transient absorption studies, supported by calculations, point to a “ping–pong” excitation transfer mechanism, significantly extending excited‐state lifetimes and offering new design principles for light‐harvesting, emissive and ...
Irene Regeni, Rituparno Chowdhury, Nicola Bogo, Kristina E. Ebbert, Jacopo Tessarolo, André Platzek, Ertugrul Yalcin, Christopher J. Stein, Sascha Feldmann, Guido H. Clever   +9 more
wiley   +2 more sources

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Metal-Free Regiodivergent Addition of Carbon Nucleophiles to α,β-Unsaturated Electrophiles

Molecules, 2017
A mild and metal-free regiodivergent addition of carbon nucleophiles to α,β-unsaturated electrophiles was developed. Total 1,2-regioselectivity was observed in the addition of nitrobenzyl chloride derivative 1 to α,β-unsaturated aldehydes 2 in the ...
Cédric Spitz, Alain G. Giuglio-Tonolo, Thierry Terme, Patrice Vanelle   +3 more
doaj   +1 more source

Unexpected reversal of the regioselectivity in Thermomyces lanuginosus lipase-catalyzed acylation of floxuridine

, 2009
Unexpected inversion of the 3':5'-regioselectivity was observed in the enzymatic methacryloylation, crotonylation and cinnamoylation of floxuridine (1.5:1, 2.3:1 and 4.4:1, respectively), where Thermomyces lanuginosus lipase preferentially catalyzed the ...
Li, Ning, Zong, Min-Hua, 马丁, Ma, Ding, Minhua Zong   +4 more
core   +1 more source

Regioselectivity of catechol O-methyltransferase confers enhancement of catalytic activity [PDF]

, 2011
Catechol O-methyltransferase (COMT) metabolizes catechol moieties by methylating a single hydroxyl group at the meta- or para- hydroxyl position. Hydrophobic amino acids near the active site of COMT influence the regioselectivity of this reaction.
Tsao, Douglas, Dokholyan, Nikolay V., Douglas Tsao, Liu, Shubin, Shubin Liu, Nikolay V. Dokholyan   +5 more
core   +1 more source

On the mechanism of the Shapiro reaction: Understanding the regioselectivity

, 2015
A detailed DFT-level mechanism elucidation of the two-step reaction of tosylhydrazones with alkyllithium reagents (the Shapiro reaction) is presented.
Funes-Ardoiz, I. [0000-0002-5843-9660], Sampedro, D. [0000-0003-2772-6453], Losantos, R. [0000-0001-5207-654X], Losantos, R., Funes-Ardoiz, I., Sampedro, D.   +5 more
core   +1 more source

Guest Transition Metals in Host Keplerate Nanocapsules as Supramolecular Inorganic Functional Mimics of Monooxygenase Enzymes

Angewandte Chemie, EarlyView.
A Keplerate, an inorganic, porous buckyball was used as a host for copper metal cations ligated by histidine surrogates. Prepared by a simple assembly technique, the guest–host complex was used as a primitive biomimetic model of a monooxygenase enzyme complex, where C─H bonds were electrocatalytically hydroxylated by oxygen under reducing conditions ...
Eynat Haviv, Hagai Cohen, Ayelet Vilan, Liat Avram, Ronny Neumann   +4 more
wiley   +2 more sources