Results 61 to 70 of about 32,974 (279)

Exploring the Potential of Cytochrome P450 CYP109B1 Catalyzed Regio—and Stereoselective Steroid Hydroxylation

Frontiers in Chemistry, 2021
Cytochrome P450 enzyme CYP109B1 is a versatile biocatalyst exhibiting hydroxylation activities toward various substrates. However, the regio- and stereoselective steroid hydroxylation by CYP109B1 is far less explored.
Xiaodong Zhang, Yun Hu, Wei Peng, Chenghua Gao, Qiong Xing, Binju Wang, Aitao Li   +6 more
doaj   +1 more source

Alkyne Hydroacylation: Switching Regioselectivity by Tandem Ruthenium Catalysis [PDF]

, 2015
By using tandem Ru-catalysis, internal alkynes can be coupled with aldehydes for the synthesis of β,γ-unsaturated ketones. The catalyst promotes alkyne transformations with high regioselectivity, with examples that include the differentiation of a methyl
Vy M. Dong (1311219), Qing-An Chen (1311222), Faben A. Cruz (1639693), Cruz, Faben A, Dong, Vy M, Chen, Qing-An   +5 more
core   +1 more source

1,1,4,4-Tetracyanobutadiene-Functionalized Anthracenes: Regioselectivity of Cycloadditions in the Synthesis of Small Near-IR Dyes [PDF]

, 2020
Two small 1,1,4,4-tetracyanobutadiene-functionalized chromophores were obtained by careful leverage of the regioselectivity of the cycloaddition reaction of tetracyanoethylene with anthracene-ynamide derivatives, inducing either a [2+2] or a [4+2] Diels ...
Trevor, Hamlin, Frédéric, Paul, Yann, Trolez, Katarzyna, Matczyszyn, Loïc, Lemiègre, Sabrinah, Batsongo-Boulingui, Anh Thy, Bui, Olivier, Mongin, ziemowit, Pokladek, Clotilde, Philippe   +9 more
core   +2 more sources

N–O Dual Functional Group Transposition via Energy Transfer Photocatalysis

Advanced Science, EarlyView.
N–O dual functional group transposition (dFGT) enabled by the photocatalytic energy transfer (EnT) has been developed. This methodology is applicable to both activated and unactivated alkyl derivatives for dFGT, and it also successfully extended to N–N dFGT, demonstrating its general applicability.
Lei Bao, Xueyu Wang, Yang Zhou, Beibei Zhan, Xiaheng Zhang   +4 more
wiley   +1 more source

Modular and Stereoselective Synthesis of Cyclobutane β‐Amino Alcohols

Angewandte Chemie, EarlyView.
Late‐stage functionalization and photoisomerization of 1,2‐azaborine leads to a general strategy for the synthesis of diversely substituted cyclobutane β‐amino alcohols. The relative stereochemistry of the resulting products is unambiguously defined by the stereospecific and stereoselective nature of the photoisomerization‐hydrogenation‐oxidation ...
Xinyu Yang, Tomoya Ozaki, Bo Li, Shih‐Yuan Liu   +3 more
wiley   +2 more sources

Tailoring Regioselectivity‐Controlled UDP‐Glycosyltransferase for Bidirectional Glycosylation of Tyrosol via Free Energy‐Driven Pocket Reshaping and Tunnel Engineering

Advanced Science
UDP‐glycosyltransferases (UGTs) are pivotal biocatalysts for synthesizing pharmaceutically valuable active components; however, their application is frequently constrained by poor regioselectivity and suboptimal catalytic efficiency.
Ziyu Zhang, Jingyi Chen, Zuozhi Liang, Wenming Shao, Zhen Gao, Bin Wu, Bingfang He, Gerhard Schenk   +7 more
doaj   +1 more source

Semi-rational engineering of an α-L-fucosidase for regioselective synthesis of fucosyl-N-acetylglucosamine disaccharides

Food Chemistry: Molecular Sciences
α-L-Fucosidases are attractive biocatalysts for the production of bioactive fucosylated oligosaccharides, however, poor regioselectivity and activity for transglycosylation have significantly limited their applications.
Peng Liu, Xiaodi Chen, Xueting Cao, Yuying Wang, Yafei Gao, Li Xu, Xukai Jiang, Min Xiao   +7 more
doaj   +1 more source

Regioselective Hydroformylation of Allylic Alcohols [PDF]

Organic Letters, 2011
A highly regioselective hydroformylation of allylic alcohols is reported toward the synthesis of β-hydroxy-acid and aldehyde products. The selectivity is achieved through the use of a ligand that reversibly binds to alcohols in situ, allowing for a directed hydroformylation to occur.
Thomas E, Lightburn, Omar A, De Paolis, Ka H, Cheng, Kian L, Tan   +3 more
openaire   +2 more sources

CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction

Advanced Science, EarlyView.
CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su, Xitao Wang, Musen Li, Guanhua Qin, Shunbo Hu, Tong‐Yi Zhang   +5 more
wiley   +1 more source

1‐Azabicyclo[1.1.0]butanes (ABBs) on the Map: Mechanistic Pathways for Catalytic Ring Opening and Functionalizations

Angewandte Chemie, EarlyView.
Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang, Hsuan‐Hung Liao   +1 more
wiley   +2 more sources