Results 81 to 90 of about 32,974 (279)
Generalizable Strategies for the Synthesis of Cereblon‐Recruiting PROTAC Prodrugs
Angewandte Chemie, EarlyView.Cereblon‐recruiting PROTACs remain challenging to derivatize for prodrug‐based delivery. In this study, three complementary conjugation strategies enabled the efficient synthesis of cleavable PROTAC prodrugs with tunable release kinetics that can be incorporated into a library of PEGylated constructs and bottlebrush prodrugs.
Aiden X. Wang +7 more
wiley +2 more sources
Regioselective Glucosylation of Pyridoxine by Microorganisms [PDF]
Bioscience, Biotechnology, and Biochemistry, 2003 Microorganisms from culture collections and isolates from nature were screened for the ability to catalyze the regioselective glucosylation of pyridoxine (PN) to produce pyridoxine 5'-alpha-D-glucoside (PN-5'-alpha-G) or pyridoxine 4'-alpha-D-glucoside (PN-4'-alpha-G).
ASANO, Yasuhisa, WADA, Koichi
openaire +2 more sources
DFT-Based Regioselectivity Criteria for Cycloaddition Reactions
, 2000 Local softness and the local HSAB principle, as defined within DFT, have attracted considerable interest since they can be used to predict regioselectivity from the electronic properties of the isolated reactants only.
Ponti A
core +1 more source
Advanced Science, EarlyView.This work reports the in situ fabrication of Escherichia coli@covalent organic frameworks (E. coli@COFs) in phosphate‐buffered saline. The COFs form an exoskeleton on E. coli, protecting intracellular β‐glucosidase (Ssbgl) while enhancing mass transfer.
Fengmei Liu +6 more
wiley +1 more source
Regioselectivity of H Cluster Oxidation
Journal of the American Chemical Society, 2011 The H(2)-evolving potential of [FeFe] hydrogenases is severely limited by the oxygen sensitivity of this class of enzymes. Recent experimental studies on hydrogenase from C. reinhardtii point to O(2)-induced structural changes in the [Fe(4)S(4)] subsite of the H cluster. Here, we investigate the mechanistic basis of this observation by means of density
Bruska MK, Stiebritz MT, Reiher M
openaire +3 more sources
Studies on the pro-oxidant chemistry of flavonoids [PDF]
, 2002 There is currently much interest in the development of functional foods aiming at the prevention of the development of some diseases, for example cancer, by the introduction of selected natural substances at elevated levels into the diet.
Awad, H.M.
core
Dual Nickel/Photoredox‐Catalyzed Regio‐ and Enantioselective Alkenylation of Epoxides
Advanced Science, EarlyView.Ni/photoredox‐catalyzed stereoconvergent cross‐electrophile coupling of racemic epoxides with alkenyl bromides is described, affording β‐alkenyl products with up to 95% ee, excellent E‐selectivity, and complete regiocontrol. These versatile intermediates enable diverse chiral synthons; mechanistic studies suggest a halide ring‐opening followed by ...
Hongyan Lan +4 more
wiley +1 more source
Angewandte Chemie, EarlyView.Development of a phosphorus‐free Ru/DBU catalyst enabling highly chemo‐ and regioselective hydroformylation of terminal olefins, sparing internal double bonds. Optimization of reaction parameters, ligand effects, and substrate scope including industrial feedstocks was realized.
Mohamed Niyaz Vellala Syed Ali +6 more
wiley +2 more sources
On the functionalization of benzo[e][2,1]thiazine
Beilstein Journal of Organic Chemistry, 2009 The reactions of benzo[e][2,1]thiazine-4-chloro-3-carbaldehydes 1 and benzo[e][2,1]thiazine-4-chloro-3-carbonitriles 2 with a number of oxidizing and reducing agents are reported.
Kirill Popov +2 more
doaj +1 more source
Chiral Fjord‐Edged Nanographenes Constructed by Allylic‐Migration‐Mediated Cyclization
Angewandte Chemie, EarlyView.A novel allylic‐migration‐mediated cyclization strategy enables the construction of two fjord‐edged nanographenes without steric blocking groups. The resulting non‐planar molecules exhibit remarkable chiroptical properties, with an absorption dissymmetry factor surpassing those of pristine [5]helicene and previously reported fjord‐edged nanographenes ...
Zhen‐Lin Qiu +7 more
wiley +2 more sources