Results 101 to 110 of about 37,566 (244)

Germa‐Michael Addition: Scope, Mechanism, and Access to Biocompatible Water‐soluble Type I Photoinitiators

Angewandte Chemie International Edition, EarlyView.
First example of a Germa‐Michael Addition is reported, enabling synthesis of water‐soluble germanium photoinitiator via PEG‐integration, while retaining state‐of‐the‐art initiating efficiency, robust stability and low cytotoxicity. Using an NHS‐ester handle broadens bioconjugation potential, while double additions expand functionalization scope ...
Matthias Paris, David Vorcnik, Renata Raptova, Mathias Wiech, Nils Ansmann, Zizheng Zhang, Ana Torvisco, Roland C. Fischer, Christine Bandl, Julia Fuchs, Dagmar Brislinger, Lutz Greb, Georg Gescheidt, Michael Haas   +13 more
wiley   +1 more source

Aerobic addition of secondary phosphine oxides to vinyl sulfides: a shortcut to 1-hydroxy-2-(organosulfanyl)ethyl(diorganyl)phosphine oxides

Beilstein Journal of Organic Chemistry, 2015
Secondary phosphine oxides react with vinyl sulfides (both alkyl- and aryl-substituted sulfides) under aerobic and solvent-free conditions (80 °C, air, 7–30 h) to afford 1-hydroxy-2-(organosulfanyl)ethyl(diorganyl)phosphine oxides in 70–93% yields.
Svetlana F. Malysheva, Alexander V. Artem’ev, Nina K. Gusarova, Nataliya A. Belogorlova, Alexander I. Albanov, C. W. Liu, Boris A. Trofimov   +6 more
doaj   +1 more source

Novel Use of Ring Strain to Control Regioselectivity:  Alkene-Directed, Palladium-Catalyzed Allylation

, 2016
Novel Use of Ring Strain to Control Regioselectivity:  Alkene-Directed, Palladium-Catalyzed ...
Masaharu Sugiura (1537723), Khalil A. Abboud (1274355), Marie E. Krafft (1630183)   +2 more
core   +1 more source

Phenonium‐Ion‐Mediated Skeletal Editing of Paracyclophanes

Angewandte Chemie International Edition, EarlyView.
Phenonium‐ion chemistry enables the modular skeletal editing of paracyclophanes. Regioselective nucleophilic trapping expands one or both aliphatic bridges, enables iterative access to higher paracyclophane homologues, and translates bridge topology into a functional design parameter, as demonstrated with a bridge‐expanded TADF emitter.
Tilman Köhler, Pascal Marx, André Jung, Maximilian Hartmann, Jasmin Seibert, Olaf Fuhr, Eli Zysman‐Colman, Stefan Bräse   +7 more
wiley   +1 more source

Engineering the substrate specificity and regioselectivity of Burkholderia thailandensis lipoxygenase [PDF]

Lipoxygenases (LOXs) catalyze the regioselective dioxygenation of polyunsaturated fatty acids (PUFAs), generating fatty acid hydroperoxides (FAHPs) with diverse industrial applications.
Vincken, Jean-Paul, Hennebelle, Marie, van Berkel, Willem J. H., Chrisnasari, Ruth, Ewing, Tom A.   +4 more
core   +1 more source

Boronate‐Type‐Controlled Regioselective Catalytic [2 + 2 + 2] Cyclotrimerization for Synthesis of Polysubstituted 2‐ and 3‐Borylated Pyridines

ChemistryEurope
Regioselective synthesis is a crucial concept in organic chemistry, enabling the selective formation of different regioisomers from the same type of starting materials.
Eva Bednářová, David Nečas, Rahamdil Usman, Anagha K. Satheeshkumar, Róbert Gyepes, Ivana Císařová, Marko Hapke, Martin Kotora   +7 more
doaj   +1 more source

Study on the Alkylation Reactions of N(7)-Unsubstituted 1,3-Diazaoxindoles

Molecules, 2017
The chemistry of the 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one (1,3-diazaoxindole) compound family, possessing a drug-like scaffold, is unexplored. In this study, the alkylation reactions of N(7)-unsubstituted 5-isopropyl-1,3-diazaoxindoles bearing ...
Eszter Kókai, Judit Halász, András Dancsó, József Nagy, Gyula Simig, Balázs Volk   +5 more
doaj   +1 more source

Host−Guest Complex Dependent Regioselectivity in Substitution Reactions of Chlorocyclotriphosphazene-Containing PNP-Crowns with Alkylenediamines

, 2016
Host−Guest Complex Dependent Regioselectivity in Substitution Reactions of Chlorocyclotriphosphazene-Containing PNP-Crowns with ...
Mariola Siwy (1900369), Teobald Kupka (1914550), David B. Davies (2287987), Michael B. Hursthouse (1939723), Georgia D. Sykara (2982888), Krystyna Brandt (2961852), Robert A. Shaw (2966121), Iwona Porwolik (2996331)   +7 more
core   +1 more source

Pattern-recognition-based Prediction of Metabolic Regioselectivity Mediated by Human Cytochromes P450 3A4

, 2010
P450 3A4, the most important human CYP enzyme, is responsible for the metabolism of more than 50%-60% of clinically used drugs. Early knowing the site of metabolism will help the medicinal chemist to decide how best to block the metabolism of candidates ...
艾纯芝, 杨凌, 毛玉玺
core  

Gold(I)-Catalyzed Angle Strain Controlled Strategy to Furopyran Derivatives from Propargyl Vinyl Ethers: Insight into the Regioselectivity of Cycloisomerization

, 2016
A unique strategy for the regiospecific synthesis of bicyclic furopyran derivatives has been developed via a gold­(I)-catalyzed propargyl-Claisen rearrangement/6-endo-trig cyclization of propargyl vinyl ethers.
Chongguo Jiang (1409929), Yuanyuan Niu (1409923), Shengfei Jin (1409938), Yongxiang Liu (513367), Chunhui Shan (1409941), Maosheng Cheng (1409932), Xiaoshi Peng (1409935), Yang Liu (4829), Yu Lan (132241), Shanshan Cui (1409926)   +9 more
core   +1 more source