Chemo- and Regioselectivity-Tunable Phosphination of Alkynes
, 2022 A divergent intramolecular phosphination of alkynes is developed. Fine tuning of chemo- and regioselectivity has been realized by just adding LiBr or H2O to give 5-exo-dig and 6-endo-dig phosphacycles, respectively.
Juan Ma +5 more
core +1 more source
Ligand-Controlled Regioselectivity in Palladium-Catalyzed Cross Coupling Reactions
, 2016 Ligand-Controlled Regioselectivity in Palladium-Catalyzed Cross Coupling ...
Franziska Schoenebeck (1266411) +1 more
core +1 more source
Fast and Accurate Prediction of the Regioselectivity of Electrophilic Aromatic Substitution Reactions [PDF]
, 2017 While computational prediction of chemical reactivity is possible it usually requires expert knowledge and there are relatively few computational tools that can be used by a bench chemist to help guide synthesis.
Jørgensen, Morten +15 more
core +1 more source
Regioselectivity in the ring opening of non-activated aziridines
, 2012 In this critical review, the ring opening of non-activated 2-substituted aziridines via intermediate aziridinium salts will be dealt with. Emphasis will be put on the relationship between the observed regioselectivity and inherent structural features ...
Michel Waroquier +15 more
core +1 more source
Regioselectivity of Birch Reductive Alkylation of Biaryls†
, 2016 The regioselectivity of the Birch reductive alkylation of polysubstituted biaryls has been investigated. Results indicate that regioselectivity is affected by the electronic nature of substituents on both aromatic rings.
Raphaël Lebeuf (2524504) +2 more
core +1 more source
Sulfur‐Directed Construction of Vinyl Cyclopropanes from 1,3‐Dienes
Angewandte Chemie International Edition, EarlyView.Sulfur takes control. A pending thioether acts as a molecular compass, directing carbene addition to the 1,3‐diene scaffold with exceptional regio‑ and diastereocontrol to forge sulfur‐substituted vinyl cyclopropanes (S‐VCPs) — molecular architectures inaccessible via conventional cyclopropanation strategies.
Anna Keimer +6 more
wiley +1 more source
An Exploratory Study of the Enzymatic Hydroxycinnamoylation of Sucrose and Its Derivatives
MoleculesPhenylpropanoid sucrose esters are a large and important group of natural substances with significant therapeutic potential. This work describes a pilot study of the enzymatic hydroxycinnamoylation of sucrose and its derivatives which was carried out ...
Matej Cvečko +2 more
doaj +1 more source
Late‐Stage Functionalization of Peptides on the Solid Phase
Angewandte Chemie International Edition, EarlyView.Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner +2 more
wiley +1 more source
TBAF and Cellulose Esters: Unexpected Deacylation with Unexpected Regioselectivity
, 2016 Tetrabutylammonium fluoride has been found to catalyze the deacylation of cellulose esters. More surprisingly, the deacylation is highly regioselective.
Kevin J. Edgar (1495768) +1 more
core +1 more source
Copper-promoted C5-selective bromination of 8-aminoquinoline amides with alkyl bromides
Beilstein Journal of Organic ChemistryAn efficient and practical method for the synthesis of C5-brominated 8-aminoquinoline amides via a copper-promoted selective bromination of 8-aminoquinoline amides with alkyl bromides was developed.
Changdong Shao +10 more
doaj +1 more source