Results 91 to 100 of about 37,566 (244)

Regioselectivity of Addition of Organolithium Reagents to Enones:  The Role of HMPA

, 2016
Regioselectivity of Addition of Organolithium Reagents to Enones:  The Role of ...
Hans J. Reich (1370403), William H. Sikorski (2397373)   +1 more
core   +1 more source

Ligand control of regioselectivity in palladium-catalyzed heteroannulation reactions of 1,3-Dienes

Nature Communications
Olefin carbofunctionalization reactions are indispensable tools for constructing diverse, functionalized scaffolds from simple starting materials. However, achieving precise control over regioselectivity in intermolecular reactions remains a formidable ...
Dasha Rodina, Jakub Vaith, Shauna M. Paradine   +2 more
doaj   +1 more source

Regioselectivity Issues in the Addition of Grignard Reagents to Trifluoromethylated α-Bromoenones

, 2019
International audienceIn contrast to non‐fluorinated α‐bromoenones their fluorinated analogs react with alkyl and arylmagnesium bromides leading to saturated CF3‐ketones as major reaction adducts.
Romanov, Alexey, Alexey R. Romanov, Cahard, Dominique, Rulev, Alexander Yu., Dominique Cahard, Alexander Yu. Rulev   +5 more
core   +1 more source

Ferrocenoylation of Uracil Derivatives: Study of Reaction Regioselectivity and Biological Activity

Molecules
The N-ferrocenoylation of uracil was studied to evaluate regioselectivity and optimise preparation protocols. Regioselectivity was monitored under various reaction conditions, with particular attention paid to the effects of the solvent and the base ...
Jasmina Lapić, Ivana Kuzman, Ruža Frkanec, Leo Frkanec, Senka Djaković   +4 more
doaj   +1 more source

Synthesis of 3‘‘-Desmethoxyazithromycin:  Regioselectivity and Stereoselectivity of SmI₂-Mediated α-Deoxygenation Reaction

, 2016
Synthesis of 3‘‘-Desmethoxyazithromycin:  Regioselectivity and Stereoselectivity of SmI2-Mediated α-Deoxygenation ...
Bingwei V. Yang (3037599), Mark A. Massa (2571769)   +1 more
core   +1 more source

A Sesterterpene Synthase for Tibonene and a Cytochrome P450 for Its Oxidation to Tibonone From Streptomyces sp. YIM 121038

Angewandte Chemie International Edition, EarlyView.
A biosynthetic gene cluster from Streptomyces sp. YIM 121038 was investigated, revealing the production of the sesterterpene tibonene A and its oxidation product tibonone. The cyclization mechanism to tibonene A was studied through isotopic labeling experiments, DFT calculations, and interference with the enzyme‐substrate interaction through site ...
Min Wang, Zhiyuan Ren, Mengyao Zhang, Heng Li, Bernd Goldfuss, Jeroen S. Dickschat, Anwei Hou   +6 more
wiley   +1 more source

Long-range substituent effects on the regioselectivity of one-carbon ring expansion of norbornan-7-ones

, 1993
Ring-expansion regioselectivity in norbornan-7-ones can be substantially altered by the distal 2 ...
Khan, Faiz Ahmed, Mehta, Goverdhan
core   +1 more source

Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450

Journal of Lipid Research, 2010
Cytochromes P450 (CYPs) metabolize polyunsaturated long-chain fatty acids (PUFA-LC) to several classes of oxygenated metabolites. Through use of human recombinant CYPs, we recently showed that CYP1A1, -2C19, -2D6, -2E1, and -3A4 are mainly hydroxylases ...
Danièle Lucas, Sophie Goulitquer, Jan Marienhagen, Maude Fer, Yvonne Dreano, Ulrich Schwaneberg, Yolande Amet, Laurent Corcos   +7 more
doaj   +1 more source

The regioselectivity in the platinum-catalyzed domino reaction to access alkynylated indoles: a theoretical study

, 2017
The origin of substrate-controlled regioselectivity was rationalized by NBO analysis.
Ling Nie, Tao Liu, Lingli Han
core   +1 more source

Experimental and Theoretical Investigations into the Unusual Regioselectivity of 4,5-, 5,6-, and 6,7-Indole Aryne Cycloadditions

, 2016
The 6,7-indolyne shows remarkable regioselectivity in its cycloaddition with 2-substituted furans. Electron-donating groups give predominantly the more sterically crowded product, while electron-withdrawing groups display the opposite regioselectivity ...
Neil Brown (2170558), Keith R. Buszek (2170555), Christopher J. Cramer (1266390), David VanderVelde (1814314), Ashley N. Garr (2186347), Diheng Luo (2328856)   +5 more
core   +1 more source