Results 51 to 60 of about 48,499 (273)
Unexpected = 4 + 2 Cycloaddition through Chromium Non-Heteroatom-Stabilized Alkynyl Carbene Complexes: Regioselective Access to Substituted 6-Azaindoles [PDF]
, 2018 This research was supported by the Spanish Government MINECO/FEDER (CTQ-2016-76840-R and CTQ-2017-87372-P (AEI/FEDER, UE)) and the Principality of Asturias, Spain (GRUPIN14 ...
Funes Ardoiz, Ignacio +3 more
core +2 more sources
Advanced Science, EarlyView.A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang +9 more
wiley +1 more source
One‐Pot Amidation/C─H Halogenation by an Efficient Electrochemical Cascade
Angewandte Chemie, EarlyView.A sustainable electrochemical cascade enables the one‐pot synthesis of regioselectively halogenated N‐aryl amides from readily available amines and acyl halides under mild conditions. The method merges amidation and C─H halogenation in a single operational step, delivering broad substrate scope, high selectivity, and scalability, and provides an ...
Sudipta Ponra +8 more
wiley +2 more sources
MoleculesIdentifying the catalytic regioselectivity of enzymes remains a challenge. Compared to experimental trial-and-error approaches, computational methods like molecular dynamics simulations provide valuable insights into enzyme characteristics.
Yi Li +3 more
doaj +1 more source
Relative Strength of Common Directing Groups in Palladium-Catalyzed Aromatic C−H Activation
iScience, 2019 Summary: Efficient functionalization of C−H bonds can be achieved using transition metal catalysts, such as Pd(OAc)2. To better control the regioselectivity in these reactions, some functional groups on the substrate may be used as directing groups ...
Anna Tomberg +5 more
doaj +1 more source
Frontiers in Chemistry, 2021 Cytochrome P450 enzyme CYP109B1 is a versatile biocatalyst exhibiting hydroxylation activities toward various substrates. However, the regio- and stereoselective steroid hydroxylation by CYP109B1 is far less explored.
Xiaodong Zhang +6 more
doaj +1 more source
Revisiting the mechanism of the mono nuclear copper-catalyzed cycloaddition of azide and alkynes (CuAAC) by the topology of .... [PDF]
, 2013 Comunicación presentada y aceptada en el CHITEL2013, XXXIX International Conference THEORETICAL CHEMISTS OF LATIN EXPRESSION (XXXIX Congreso Internacional de Químicos de Expresión Latina).Se analiza el mecanismo de la reacción de cicloadición, catalizada
Calvo-Losada, Saturnino +2 more
core
Nickel‐Catalyzed Twofold Conjunctive Coupling via Philicity‐Alternating Radical Relay
Advanced Science, EarlyView.Herein, we disclose a nickel‐catalyzed twofold conjunctive coupling that enables a four‐component assembly involving an activated alkene, a 1,3‐enyne, and both alkyl and aryl halides. Multiple C–C bonds are selectively constructed through a philicity‐alternating radical relay and the selective radical capture by the nickel catalyst.
Ji Hwan Jeon +7 more
wiley +1 more source
Food Chemistry: Molecular Sciencesα-L-Fucosidases are attractive biocatalysts for the production of bioactive fucosylated oligosaccharides, however, poor regioselectivity and activity for transglycosylation have significantly limited their applications.
Peng Liu +7 more
doaj +1 more source
Heterogeneous Catalysts in Pictet-Spengler-Type Reactions
Journal of Chemistry, 2013 Several solid catalysts were evaluated as an alternative for 1,2,3,4-tetrahydroisoquinoline synthesis by means of the Pictet-Spengler reaction. The reaction catalysed by a mixed oxide (Mg and Al) led to the best yield and good regioselectivity; using an ...
Rodolfo Quevedo +2 more
doaj +1 more source