Results 91 to 100 of about 3,880,374 (297)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

MODELING TOTAL FERTILITY RATE IN INDONESIA: A COMPARISON OF FOURIER SERIES REGRESSION AND ELASTIC NET REGRESSION

Barekeng
The Total Fertility Rate (TFR) describes population growth and socioeconomic development of a country. This statistic plays an important role in predicting future social and economic conditions.
Fadhilah Fitri, Melin Wanike Ketrin, Mawanda Almuhayar   +2 more
doaj   +1 more source

Currency Exchange Rate Forecasts Using Quantile Regression

, 2016
{"references": ["Koenker, R. (2005). Quantiles Regression. Cambridge University Press.", "Cai, Y., Stander, J. and Davies, N. (2012). A new Bayesian approach\nto quantile autoregressive time series model estimation and forecasting.\nJournal of Time Series Analysis, 33, 684-698.", "Taylor, J. W. (2007).
openaire   +2 more sources

Spatiotemporal incidence rate data analysis by nonparametric regression

Statistics in Medicine, 2018
To monitor the incidence rates of cancers, AIDS, cardiovascular diseases, and other chronic or infectious diseases, some global, national, and regional reporting systems have been built to collect/provide population‐based data about the disease incidence.
Kai Yang, Peihua Qiu
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Testing and Modeling Fuel Regression Rate in a Miniature Hybrid Burner

International Journal of Aerospace Engineering, 2012
Ballistic characterization of an extended group of innovative HTPB-based solid fuel formulations for hybrid rocket propulsion was performed in a lab-scale burner. An optical time-resolved technique was used to assess the quasisteady regression history of
Luciano Fanton, Christian Paravan, Luigi T. De Luca   +2 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Application of regression tress for prediction of water conduits failure rate

E3S Web of Conferences, 2017
This paper presents the results of predicting the failure rate of water distribution pipes and house connections in a selected city in Poland by means of regression trees. Several regression tree models were built as part of modelling.
Kutyłowska Małgorzata
doaj   +1 more source

Relation between the compaction rate and physical and mechanical properties of particleboards

Materials Research, 2005
The compaction rate, the relation between the density of the wood panel and the density of the wood used for producing the particles, is an indicator of the product's densification.
Fabricio Moura Dias, Maria Fátima do Nascimento, Mariano Martinez-Espinosa, Francisco Antonio Rocco Lahr, Ivaldo de Domenico Valarelli   +4 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source