Results 61 to 70 of about 2,020,990 (315)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The Three-Dimensional Transient Simulation of Cross-Shaped Grains in Hybrid Rocket Motors

Aerospace
The process of spacecraft entry, deceleration, landing, and ascent requires high specific impulse, high reliability, and high-precision thrust adjustments for the power system.
Xiangyu Meng, Huihuang Huang, Yifei Chen, Mingsen Yao, Jianyuan Wang, Hui Tian   +5 more
doaj   +1 more source

Predicting Crash Rate Using Logistic Quantile Regression With Bounded Outcomes

IEEE Access, 2017
Various approaches and perspectives have been presented in safety analysis during the last decade, but when some continuous outcome variables take on values within a bounded interval, the conventional statistical methods may be inadequate, and frequency ...
Xuecai Xu, Li Duan
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Approaches to Low Fuel Regression Rate in Hybrid Rocket Engines

International Journal of Aerospace Engineering, 2012
Hybrid rocket engines are promising propulsion systems which present appealing features such as safety, low cost, and environmental friendliness. On the other hand, certain issues hamper the development hoped for.
Dario Pastrone
doaj   +1 more source

Review of Classical Diffusion-Limited Regression Rate Models in Hybrid Rockets

Aerospace, 2019
In this article, we undertake a concise review of several milestone developments in classical regression rate models of hybrid rocket motors. After a brief description of the physical processes entailed in hybrid rocket combustion, Marxman’s ...
Timothy Marquardt, Joseph Majdalani
doaj   +1 more source

Inflation Rate Prediction in Indonesia using Optimized Support Vector Regression Model

JITeCS (Journal of Information Technology and Computer Science), 2020
Inflation is a indicator which illustrated the economics condition of a country. This moneter phenomenom is signed with the increase of price in entire case. It can cause an effect for political sector which impact to economic stability in a nation.
Irvi Oktanisa, Wayan Firdaus Mahmudy, Ghozali Maski   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Regression Models and Fuzzy Logic Prediction of TBM Penetration Rate

Open Engineering, 2017
This paper presents statistical analyses of rock engineering properties and the measured penetration rate of tunnel boring machine (TBM) based on the data of an actual project.
Minh Vu Trieu, Katushin Dmitri, Antonov Maksim, Veinthal Renno   +3 more
doaj   +1 more source