Results 131 to 140 of about 1,906,383 (319)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Threonine deaminase from Escherichia coli. II. Maturation and physical properties of the enzyme from a mutant altered in its regulation of gene expression.

, 1975
David H. Calhoun, J Kuska, G. Wesley Hatfield   +2 more
openalex   +1 more source

Regulation of Gene Expression in Cancer-An Overview. [PDF]

Cells, 2022
Ferlier T, Coulouarn C.
europepmc   +1 more source

Local regulation of gene expression by lncRNA promoters, transcription and splicing

Nature, 2016
J. Engreitz, Jenna E Haines, Elizabeth M. Perez, Glen Munson, Jenny Chen, Michael Kane, P. McDonel, M. Guttman, E. Lander   +8 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Plant nuclear envelope as a hub connecting genome organization with regulation of gene expression. [PDF]

Nucleus, 2023
Tang Y.
europepmc   +1 more source

Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression

Cellular and Molecular Life Sciences, 2018
Meng-fan Pu, J. Chen, Zhouteng Tao, Ling-ling Miao, X. Qi, Yizheng Wang, Jin-ping Ren   +6 more
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Genetic variability in the regulation of gene expression in ten regions of the human brain

Nature Neuroscience, 2014
A. Ramasamy, D. Trabzuni, S. Guelfi, Vibin Varghese, Colin Smith, R. Walker, Tisham De, L. Coin, R. Silva, M. Cookson, A. Singleton, J. Hardy, M. Ryten, M. Weale   +13 more
semanticscholar   +1 more source