Results 51 to 60 of about 2,700,809 (357)
A linear mixed model approach to gene expression-tumor aneuploidy association studies. [PDF]
, 2019 Aneuploidy, defined as abnormal chromosome number or somatic DNA copy number, is a characteristic of many aggressive tumors and is thought to drive tumorigenesis.
Balanis, Nikolas G +3 more
core
Arabidopsis thaliana DOF6 negatively affects germination in non-after ripened seeds and interacts with TCP14 [PDF]
, 2011 Seed dormancy prevents seeds from germinating under environmental conditions unfavourable for plant growth and development and constitutes an evolutionary advantage.
Barrero Sicilia, Cristina +4 more
core +3 more sources
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity
Nature Communications, 2018 CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tumor ...
Sergey Karakashev +14 more
doaj +1 more source
Consequences of early life stress on genomic landscape of H3K4me3 in prefrontal cortex of adult mice
BMC Genomics, 2018 Background Maternal separation models in rodents are widely used to establish molecular mechanisms underlying prolonged effects of early life adversity on neurobiological and behavioral outcomes in adulthood.
Nikita I. Ershov +5 more
doaj +1 more source
Long-Term Memory Formation in Drosophila Depends on the 3′UTR of CPEB Gene orb2
Cells, 2023 Activation of local translation in neurites in response to stimulation is an important step in the formation of long-term memory (LTM). CPEB proteins are a family of translation factors involved in LTM formation. The Drosophila CPEB protein Orb2 plays an
Eugene N. Kozlov +10 more
doaj +1 more source
Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes. [PDF]
, 2014 With defined culture protocol, human embryonic stem cells (hESCs) are able to generate cardiomyocytes in vitro, therefore providing a great model for human heart development, and holding great potential for cardiac disease therapies.
Benner, Christopher +15 more
core +3 more sources
Nutritional regulation of gene expression
The American Journal of Medicine, 1999 Genes are regulated by complex arrays of response elements that influence the rate of transcription. Nutrients and hormones either act directly to influence these rates or act indirectly through specialized signaling pathways. Metabolites of vitamins A and D, fatty acids, some sterols, and zinc are among the nutrients that influence transcription ...
Center for Nutritional Sciences and Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida, USA ( host institution ) +1 more
openaire +3 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Nature Communications, 2019 Progressive familial intrahepatic cholestasis type 3 is a disease caused by mutations in the gene encoding the multidrug resistance protein 3, and has limited treatment options.
Nicholas D. Weber +7 more
doaj +1 more source