Results 11 to 20 of about 303,937 (307)

Epigenetic and epitranscriptomic regulation of viral replication. [PDF]

Nat Rev Microbiol, 2020
Eukaryotic gene expression is regulated not only by genomic enhancers and promoters, but also by covalent modifications added to both chromatin and RNAs. Whereas cellular gene expression may be either enhanced or inhibited by specific epigenetic modifications deposited on histones (in particular, histone H3), these epigenetic modifications can also ...
Tsai K, Cullen BR.
europepmc   +4 more sources

Host cytoskeleton and membrane network remodeling in the regulation of viral replication. [PDF]

Biophys Rep
Viral epidemics pose major threats to global health and economies. A hallmark of viral infection is the reshaping of host cell membranes and cytoskeletons to form organelle-like structures, known as viral factories, which support viral genome replication. Viral infection in many cases induces the cytoskeletal network to form cage-like structures around
Gao X, Chen X, Yu L, Zhao S, Jiu Y.
europepmc   +3 more sources

Psoralen inhibits hepatitis B viral replication by down-regulating the host transcriptional machinery of viral promoters

Virologica Sinica, 2022
The hepatitis B virus (HBV) is a global public health challenge due to its highly contagious nature. It is estimated that almost 300 million people live with chronic HBV infection annually. Although nucleoside analogs markedly reduce the risk of liver disease progression, the analogs do not fully eradicate the virus.
Xinna Ma, Heng Li, Ying Gong, Feifei Liu, Xiankun Tong, Fenghua Zhu, Xiaoqian Yang, Li Yang, Jianping Zuo   +8 more
openaire   +2 more sources

PSMD12-Mediated M1 Ubiquitination of Influenza A Virus at K102 Regulates Viral Replication

Journal of Virology, 2022
M1 is proposed to play multiple biologically important roles in the life cycle of IAV, which relies largely on host factors. This study is the first one to identify that PSMD12 interacts with M1, mediates K63-linked ubiquitination of M1 at the K102 site, and thus positively regulates influenza virus proliferation.
Xianfeng Hui, Lei Cao, Ting Xu, Lianzhong Zhao, Kun Huang, Zhong Zou, Peilei Ren, Haiying Mao, Ying Yang, Shuo Gao, Xiaomei Sun, Xian Lin, Meilin Jin   +12 more
openaire   +2 more sources

Epitranscriptomic regulation of viral replication

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2017
RNA plays central roles in biology and novel functions and regulation mechanisms are constantly emerging. To accomplish some of their functions within the cell, RNA molecules undergo hundreds of chemical modifications from which N6-methyladenosine (m6A), inosine (I), pseudouridine (ψ) and 5-methylcytosine (5mC) have been described in eukaryotic mRNA ...
Pereira-Montecinos, Camila, Valiente-Echeverría, Fernando, Soto Rifo, Ricardo   +2 more
openaire   +3 more sources

Keratinocyte differentiation-dependent human papillomavirus gene regulation [PDF]

, 2017
Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte.
Graham, Sheila V.
core   +1 more source

Annexin A1 Negatively Regulates Viral RNA Replication of Hepatitis C Virus

Annexin A1 Negatively Regulates Viral RNA Replication of Hepatitis C Virus, 2016
Persistent infection with hepatitis C virus (HCV) often causes chronic hepatitis, and then shows a high rate of progression to liver cirrhosis and hepatocellular carcinoma. To clarify the mechanism of the persistent HCV infection is considered to be important for the discovery of new target(s) for the development of anti-HCV strategies.
Hiramoto, Hiroki, Dansako, Hiromichi, Takeda, Midori, Satoh, Shinya, Wakita, Takaji, Ikeda, Masanori, Kato, Nobuyuki   +6 more
openaire   +3 more sources

Human Cytomegalovirus UL34 Early and late Proteins Are Essential for Viral Replication

Viruses, 2014
UL34 is one of the ~50 genes of human cytomegalovirus (HCMV) required for replication in cell culture in human fibroblasts. UL34 encodes highly related early (UL34a) and late (UL34b) proteins that are virtually identical, with the early protein ...
Rico Rana, Bonita J. Biegalke
doaj   +1 more source

Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes [PDF]

, 2013
Death domain–associated protein (Daxx) cooperates with X-linked α-thalassaemia retardation syndrome protein (ATRX), a putative member of the sucrose non-fermentable 2 family of ATP-dependent chromatin-remodelling proteins, acting as the core ATPase ...
Andreas Mund, Badens, Baker, Berk, Berube, Blanchette, Carolin Bürck, Chatterjee, Cheng, Chinnadurai, Cuchet-Lourenco, Dallaire, Dellaire, Dobner, Drane, Everett, Flint, Frisch, Gibbons, Glass, Goldberg, Goldberg, Gostissa, Graham, Groitl, Gunther, Hancock, Harlow, Hassan, Hollenbach, Ishov, Ishov, Jin, Kahyo, Kindsmuller, Kindsmuller, Kindsmüller, Ko, Komatsu, Kosulin, Lewis, Lewis, Li, Lukashchuk, Lukashchuk, Mandy Glass, Marton, Matsumoto, Maul, McFarlane, Michaelson, Mitsudomi, Mund, Nevels, Nevins, Nevins, Niforou, Okuwaki, Orazio, Parks, Pelka, Peter Groitl, Peter Wimmer, Placek, Querido, Roger D. Everett, Ross, Rubenwolf, Sabrina Schreiner, Salomoni, Sarah Kinkley, Sarnow, Schreiner, Schreiner, Schreiner, Shenk, Si, Song, Stracker, Takahashi, Tang, Thomas Dobner, Torii, Täuber, Täuber, Ullman, White, Williams, Wilson, Wong, Wong, Xu, Xue   +92 more
core   +1 more source

Vesicular stomatitis virus in Drosophila melanogaster cells: regulation of viral transcription and replication [PDF]

Journal of Virology, 1988
Vesicular stomatitis virus RNA synthesis was investigated during the establishment of persistent infection in Drosophila melanogaster cells. The transcription rate declined as early as 5 h after infection and was strongly inhibited after 7 h, leading to a decrease in viral mRNA levels and in viral protein synthesis rates.
D, Blondel, A M, Petitjean, S, Dezélée, F, Wyers   +3 more
openaire   +2 more sources