Molecular components of the circadian clock regulate HIV-1 replication
iScience, 2023 Summary: Human immunodeficiency virus 1 (HIV-1) causes major health burdens worldwide and still lacks curative therapies and vaccines. Circadian rhythms are endogenous daily oscillations that coordinate an organism’s response to its environment and ...
Helene Borrmann +11 more
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Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands [PDF]
, 1998 Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis.
Baird, Eldon E. +6 more
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Viral precursor polyproteins: keys of regulation from replication to maturation
Current Opinion in Virology, 2013 Many viruses use a replication strategy involving the translation of a large polyprotein, which is cleaved by viral and/or cellular proteases. Several of these viruses severely impact human health around the globe, including HIV, HCV, Dengue virus, and West Nile virus.
Yost, Samantha A, Marcotrigiano, Joseph
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The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state [PDF]
, 2016 Indexación: Web of ScienceWith about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte ...
Alarcon, V +9 more
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Molecular Systems Biology, 2010 The search for effective Hepatitis C antiviral therapies has recently focused on host sterol metabolism and protein prenylation pathways that indirectly affect viral replication. However, inhibition of the sterol pathway with statin drugs has not yielded
Christopher M Owens +7 more
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Reactivation and Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus: An Update
Frontiers in Microbiology, 2017 The life cycle of Kaposi’s sarcoma-associated herpesvirus (KSHV) consists of two phases, latent and lytic. The virus establishes latency as a strategy for avoiding host immune surveillance and fusing symbiotically with the host for lifetime persistent ...
Yan Yuan, Kawalpreet K. Aneja
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Understanding the Wolbachia-mediated inhibition of arboviruses in mosquitoes: progress and challenges [PDF]
, 2014 Arthropod-borne viruses (arboviruses) pose a considerable threat to human and animal health, yet effective control measures have proven difficult to implement, and novel means of controlling their replication in arthropod vectors, such as mosquitoes, are
Dietrich, Isabelle +3 more
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IFN-Gamma Inhibits JC Virus Replication in Glial Cells by Suppressing T-Antigen Expression. [PDF]
PLoS ONE, 2015 Patients undergoing immune modulatory therapies for the treatment of autoimmune diseases such as multiple sclerosis, and individuals with an impaired-immune system, most notably AIDS patients, are in the high risk group of developing progressive ...
Francesca Isabella De-Simone +6 more
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TMP269, a small molecule inhibitor of class IIa HDAC, suppresses RABV replication in vitro
Frontiers in Microbiology, 2023 TMP269, a small molecular inhibitor of IIa histone deacetylase, plays a vital role in cancer therapeutic. However, the effect of TMP269 on the regulation of viral replication has not been studied.
Juanbin Yin +8 more
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Regulation of alphaherpesvirus infections by the ICP0 family of proteins [PDF]
, 2013 Immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1) is important for the regulation of lytic and latent viral infection. Like the related proteins expressed by other alphaherpesviruses, ICP0 has a zinc-stabilized RING finger domain that ...
Boutell, Chris, Everett, Roger
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