Results 91 to 100 of about 5,375,401 (399)

Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients

Nature Communications, 2020
Speciation is associated with substantial rewiring of the regulatory circuitry underlying the expression of genes. Determining which changes are relevant and underlie the emergence of the human brain or its unique susceptibility to neural disease has ...
B. Castelijns, M. Baak, I. Timpanaro, C. Wiggers, M. Vermunt, Peng Shang, I. Kondova, G. Geeven, Valerio Bianchi, W. de Laat, N. Geijsen, M. Creyghton   +11 more
semanticscholar   +1 more source

Cis-regulatory elements and human evolution [PDF]

Current Opinion in Genetics & Development, 2014
AbstractModification of gene regulation has long been considered an important force in human evolution, particularly through changes tocis-regulatory elements (CREs) that function in transcriptional regulation. For decades, however, the study ofcis-regulatory evolution was severely limited by the available data.
Adam Siepel, Leonardo Arbiza
openaire   +2 more sources

Predicting the Future Burden of Renal Replacement Therapy in Türkiye Using National Registry Data and Comparative Modeling Approaches

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic kidney disease is a growing public health problem worldwide, and the number of patients requiring renal replacement therapy is steadily increasing. Türkiye has experienced a similar rise in both the incidence and prevalence of renal replacement therapy over the past decades; however, national‐level projections of future ...
Arzu Akgül, Neriman Sıla Koç, Berrak Itır Aylı   +2 more
wiley   +1 more source

FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin [PDF]

Genome Research, 2006
DNA segments that actively regulate transcription in vivo are typically characterized by eviction of nucleosomes from chromatin and are experimentally identified by their hypersensitivity to nucleases. Here we demonstrate a simple procedure for the isolation of nucleosome-depleted DNA from human chromatin, termed FAIRE (Formaldehyde-AssistedIsolation ...
Paul G, Giresi, Jonghwan, Kim, Ryan M, McDaniell, Vishwanath R, Iyer, Jason D, Lieb   +4 more
openaire   +2 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Nuclear U1 snRNA facilitates the dimerization of hnRNPA2B1 to enhance anti-DNA viral innate immunity

Cell Reports
Summary: Housekeeping U1 small nuclear RNA (snRNA) is mainly located in the nucleus, which is essential for RNA splicing. Here, we show that seven U1 genes and mature U1 snRNA are upregulated in the nucleoplasm during DNA virus HSV-1 infection ...
Fan Zhang, Zigang Qiao, Yuansong Wei, Siying Liu, Shiyou Wang, Tao Yang, Lichen Yin, Feng Ma   +7 more
doaj   +1 more source

Regulatory Network Identification, Promoter and Expression Analysis of Arabidopsis thaliana NPR1 in Defense Responses against Stresses

Notulae Scientia Biologicae, 2018
Salicylic acid (SA) and jasmonic acid (JA) phytohormones have been known for their roles in plant defense behaviour against biotic and abiotic stresses. They regulate defense pathways by antagonistic interaction.
Amir G. SHAHRIARI, Aminallah TAHMASEBI, Sima SAZEGARI   +2 more
doaj   +1 more source

Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements. [PDF]

, 2019
Pooled CRISPR-Cas9 screens are a powerful method for functionally characterizing regulatory elements in the non-coding genome, but off-target effects in these experiments have not been systematically evaluated.
Aradhana, Bassik, Michael C, Bintu, Lacramioara, Ego, Braeden K, Greenleaf, William J, Greenside, Peyton G, Hess, Gaelen T, Kaplow, Irene M, Kundaje, Anshul, Li, Amy, Marinov, Georgi K, Morgens, David W, Phanstiel, Douglas H, Snyder, Michael P, Spees, Kaitlyn, Trevino, Alexandro E, Truong, Alisa, Tycko, Josh, Ursu, Oana, Wainberg, Michael, Yao, David   +20 more
core  

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Mapping of Variable DNA Methylation Across Multiple Cell Types Defines a Dynamic Regulatory Landscape of the Human Genome

G3: Genes, Genomes, Genetics, 2016
DNA methylation is an important epigenetic modification involved in many biological processes and diseases. Many studies have mapped DNA methylation changes associated with embryogenesis, cell differentiation, and cancer at a genome-wide scale.
Junchen Gu, Michael Stevens, Xiaoyun Xing, Daofeng Li, Bo Zhang, Jacqueline E. Payton, Eugene M. Oltz, James N. Jarvis, Kaiyu Jiang, Theodore Cicero, Joseph F. Costello, Ting Wang   +11 more
doaj   +1 more source