Results 91 to 100 of about 5,141,166 (402)

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Post-transcriptional Regulation by 3′ UTRs Can Be Masked by Regulatory Elements in 5′ UTRs

Cell Reports, 2018
Summary: In mRNA sequences, 3′ UTRs are thought to contain most elements that specifically regulate localization, turnover, and translation. Although high-throughput experiments indicate that many RNA-binding proteins (RBPs) also bind 5′ UTRs, much less ...
Kathrin Theil, Margareta Herzog, Nikolaus Rajewsky   +2 more
doaj  

Comprehensive Analysis of Key Genes and Regulatory Elements in Osteosarcoma Affected by Bone Matrix Mineral With Prognostic Values

Frontiers in Genetics, 2020
Osteosarcoma is one of the most common types of bone sarcoma with a poor prognosis. However, genes involved in the mineral metabolism in the microenvironment of the bone affected by osteosarcoma are, to date, largely unknown.
Mi Li, Xin Jin, Hao Li, Caihong Yang, Sisi Deng, Gang Wu   +5 more
doaj   +1 more source

Primary transcriptome and translatome analysis determines transcriptional and translational regulatory elements encoded in the Streptomyces clavuligerus genome

Nucleic Acids Research, 2019
Determining transcriptional and translational regulatory elements in GC-rich Streptomyces genomes is essential to elucidating the complex regulatory networks that govern secondary metabolite biosynthetic gene cluster (BGC) expression.
Soonkyu Hwang, Namil Lee, Yujin Jeong, Yongjae Lee, Woori Kim, Suhyung Cho, B. Palsson, Byung-Kwan Cho   +7 more
semanticscholar   +1 more source

Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements. [PDF]

, 2019
Pooled CRISPR-Cas9 screens are a powerful method for functionally characterizing regulatory elements in the non-coding genome, but off-target effects in these experiments have not been systematically evaluated.
Aradhana, Bassik, Michael C, Bintu, Lacramioara, Ego, Braeden K, Greenleaf, William J, Greenside, Peyton G, Hess, Gaelen T, Kaplow, Irene M, Kundaje, Anshul, Li, Amy, Marinov, Georgi K, Morgens, David W, Phanstiel, Douglas H, Snyder, Michael P, Spees, Kaitlyn, Trevino, Alexandro E, Truong, Alisa, Tycko, Josh, Ursu, Oana, Wainberg, Michael, Yao, David   +20 more
core  

Design principles for riboswitch function [PDF]

, 2009
Scientific and technological advances that enable the tuning of integrated regulatory components to match network and system requirements are critical to reliably control the function of biological systems. RNA provides a promising building block for the
A Belle, A Levchenko, A Zaslaver, Adam P. Arkin, B Suess, B Suess, CA Voigt, Chase L. Beisel, Christina D. Smolke, CI An, CL Beisel, DH Mathews, DJ Klein, DM Crothers, DW Selinger, E Dekel, FJ Isaacs, FJ Isaacs, GJ Leclerc, GM Emilsson, GM Suel, GR Zimmermann, HM Al-Hashimi, J Tomsic, JA Bernstein, JA Collins, JE Barrick, JF Lemay, JK Wickiser, JK Wickiser, K Lang, LJ Su, LV Danilova, M Acar, M Parisien, MN Win, MN Win, MR Bennett, MT Cheah, MT Woodside, N Hao, O Kensch, P Corish, PP Zarrinkar, PT Li, R Narsai, R Rieder, RD Jenison, RR Breaker, S Topp, S Topp, SA Lynch, SE Osborne, SK Desai, T Pan, TH Lee, TS Bayer, WC Winkler, WC Winkler, WJ Greenleaf, X Zhang, X Zhuang, Y Yokobayashi   +62 more
core   +4 more sources

ModHMM: A Modular Supra-Bayesian Genome Segmentation Method [PDF]

, 2020
Genome segmentation methods are powerful tools to obtain cell type or tissue-specific genome-wide annotations and are frequently used to discover regulatory elements.
Benner, P., Vingron, M.
core   +2 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Identification and dynamic quantification of regulatory elements using total RNA

Genome Research, 2019
The spatial and temporal regulation of transcription initiation is pivotal for controlling gene expression. Here, we introduce capped-small RNA-seq (csRNA-seq), which uses total RNA as starting material to detect transcription start sites (TSSs) of both ...
Sascha H. C. Duttke, M. Chang, S. Heinz, C. Benner   +3 more
semanticscholar   +1 more source

Genetic determinants of co-accessible chromatin regions in activated T cells across humans. [PDF]

, 2018
Over 90% of genetic variants associated with complex human traits map to non-coding regions, but little is understood about how they modulate gene regulation in health and disease.
A Barrie, A Battle, A Franke, AA Shabalin, AM Klein, AR Quinlan, Atsede Siba, Aviv Regev, Aviva P. Aiden, B Li, BE Stranger, C Hou, Christine S. Cheng, Christophe Benoist, Chun J. Ye, CJ Ye, CK Stroud, D Hnisz, D Lee, D Sakata, DE Speiser, Dmytro Lituiev, E Elinav, E Splinter, EM Schmidt, Erez Lieberman Aiden, EZ Macosko, G Jun, G McVicker, H Kilpinen, H Li, H Li, HK Finucane, HM Kang, Howard Y. Chang, Ido Machol, Ivo Wortman, J Yang, JD Buenrostro, JD Buenrostro, JD Storey, JE Phillips, JF Degner, JN Hirschhorn, JS Delisle, K Enjyoji, Kendrick L. Hougen, KK Farh, L Chen, L Plesner, M Feuerer, M Ghandi, M Kasowski, M Kronenberg, M Kurachi, M. Grace Gordon, Marcin Tabaka, MB Gerstein, Meena Subramaniam, MI Love, MI McCarthy, Michael A. Beer, MN Lee, MT Maurano, Muhammad Shamim, MY Donath, N Kumasaka, NC Durand, Neva C. Durand, NP Restifo, P Cauchy, P Li, PC Hollenhorst, Philip L. De Jager, PM Visscher, PS Ohashi, R Satija, Rachel E. Gate, RE Thurman, RM Samstein, Roadmap Epigenomics Consortium,, S Deaglio, S Heinz, S Neph, SM Waszak, SS Rao, Su-Chen Huang, T Lappalainen, T Raj, The ENCODE Project Consortium., Ting Feng, TL Murphy, UM Marigorta, WA Whyte, WJ Astle, X Chen, X Sun, Y Belkaid, Y Zhang, YY Fan   +99 more
core   +2 more sources