Results 81 to 90 of about 1,489,667 (310)

3D Chromatin Architecture Re-Wiring at the CDH3/CDH1 Loci Contributes to E-Cadherin to P-Cadherin Expression Switch in Gastric Cancer

Biology, 2023
Cadherins are cell–cell adhesion molecules, fundamental for cell architecture and polarity. E-cadherin to P-cadherin switch can rescue adherens junctions in epithelial tumours.
Celina São José, Carla Pereira, Marta Ferreira, Ana André, Hugo Osório, Irene Gullo, Fátima Carneiro, Carla Oliveira   +7 more
doaj   +1 more source

An Exonic Splicing Enhancer within a Bidirectional Coding Sequence Regulates Alternative Splicing of an Antisense mRNA [PDF]

, 2010
The discovery of increasing numbers of genes with overlapping sequences highlights the problem of expression in the context of constraining regulatory elements from more than one gene.
Hastings, Michelle Laura, Munroe, Stephen, Rediske, Nathaniel W., Salato, Valerie K., Zhang, Chao   +4 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Protocol for siRNA-mediated U1 snRNA knockdown using fluorinated α-helical polypeptide in vitro and in vivo

STAR Protocols
Summary: Here, we present a protocol for small interfering RNA (siRNA)-mediated U1 small nuclear RNA (snRNA) knockdown using fluorinated α-helical polypeptide in macrophages and mouse lungs, providing a dependable approach to silence U1 snRNA in vitro ...
Fan Zhang, Chenglong Ge, Zigang Qiao, Yu Han, Lichen Yin, Feng Ma   +5 more
doaj   +1 more source

Mapping of Variable DNA Methylation Across Multiple Cell Types Defines a Dynamic Regulatory Landscape of the Human Genome

G3: Genes, Genomes, Genetics, 2016
DNA methylation is an important epigenetic modification involved in many biological processes and diseases. Many studies have mapped DNA methylation changes associated with embryogenesis, cell differentiation, and cancer at a genome-wide scale.
Junchen Gu, Michael Stevens, Xiaoyun Xing, Daofeng Li, Bo Zhang, Jacqueline E. Payton, Eugene M. Oltz, James N. Jarvis, Kaiyu Jiang, Theodore Cicero, Joseph F. Costello, Ting Wang   +11 more
doaj   +1 more source

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP [PDF]

, 2013
Through controlling the nuclear level of active positive transcription elongation factor b (P-TEFb), the 7SK small nuclear RNA (snRNA) functions as a key regulator of RNA polymerase II transcription.
Bayfield, Bhattacharya, Biewenga, Blazek, Chambers, Cheng, de Almeida, Diribarne, Egloff, Goodall, Gupta, Gupta, Jeronimo, Jobert, Kiss, Kiss, Kiss, L. Muniz, Markert, Michels, Muniz, Nguyen, O'Keeffe, Peterlin, Price, S. Egloff, Shimba, Shimba, Shumyatsky, Shumyatsky, Singh, Singh, Singh, T. Kiss, Takahasi, Van Herreweghe, Wada, Wassarman, Yamaguchi, Yang, Yik, Yik, Zhou, Zhou   +43 more
core   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Presenting a Meta-Heuristic Algorithm to Detect Regulatory Elements in the Genome of Breast Cancer Patients [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Nowadays, in medical sciences, the amount of data on symptoms of people affected with various illnesses on one hand, and finding assistive techniques for the diagnosis of those diseases on the other, has been widespread ...
mohammadjavad hosseinpoor, hamid parvin, samad nejatian, Vahideh Rezaee, Karamollah bagherifard   +4 more
doaj  

ENCODE: A Sourcebook of Epigenomes and Chromatin Language [PDF]

Genomics & Informatics, 2013
Until recently, since the Human Genome Project, the general view has been that the majority of the human genome is composed of junk DNA and has little or no selective advantage to the organism.
Maryam Yavartanoo, Jung Kyoon Choi
doaj   +1 more source