Results 271 to 280 of about 5,141,166 (402)

Wnt signaling activation induces CTCF binding and loop formation at <i>cis</i>-regulatory elements of target genes. [PDF]

Genome Res
Nordin A, Chakraborty C, Jonasson M, Dano O, Zambanini G, Pagella P, Remeseiro S, Cantù C.   +7 more
europepmc   +1 more source

The mouse tyrosinase gene. Promoter modulation by positive and negative regulatory elements.

, 1994
Ruth Ganß, G Schütz, Friedrich Beermann   +2 more
openalex   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Multiscale footprints reveal the organization of cis-regulatory elements. [PDF]

Nature
Hu Y, Horlbeck MA, Zhang R, Ma S, Shrestha R, Kartha VK, Duarte FM, Hock C, Savage RE, Labade A, Kletzien H, Meliki A, Castillo A, Durand NC, Mattei E, Anderson LJ, Tay T, Earl AS, Shoresh N, Epstein CB, Wagers AJ, Buenrostro JD.   +21 more
europepmc   +1 more source

Identification of cis-regulatory elements in the myelin proteolipid protein (PLP) gene.

, 1992
Jo Ann Berndt, J.G. Kim, Lynn D. Hudson
openalex   +1 more source

Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate. [PDF]

, 1993
C L Defranco, Deborah H. Damon, Mitsutoshi Endoh, John A. Wagner   +3 more
openalex   +1 more source

CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data

Nature Methods, 2018
Jonathan Y. Hsu, Jonathan Y. Hsu, C. Fulco, C. Fulco, Mitchel A. Cole, Mitchel A. Cole, Matthew C. Canver, Danilo Pellin, Danilo Pellin, F. Sher, F. Sher, Rick Farouni, Rick Farouni, Kendell Clement, Kendell Clement, Jimmy A. Guo, Luca Biasco, Luca Biasco, S. Orkin, Jesse M Engreitz, Jesse M Engreitz, Eric S. Lander, Eric S. Lander, Eric S. Lander, J. Joung, Daniel E. Bauer, Daniel E. Bauer, Luca Pinello, Luca Pinello   +28 more
semanticscholar   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

De novo design of insulated cis-regulatory elements based on deep learning-predicted fitness landscape. [PDF]

Nucleic Acids Res
Wang H, Xiang Y, Liu Z, Yin W, Li B, Qian L, Wang X, Lou C.   +7 more
europepmc   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source