Results 41 to 50 of about 5,141,166 (402)

The transcriptome dynamics of single cells during the cell cycle

Molecular Systems Biology, 2020
The cell cycle is among the most basic phenomena in biology. Despite advances in single‐cell analysis, dynamics and topology of the cell cycle in high‐dimensional gene expression space remain largely unknown.
Daniel Schwabe, Sara Formichetti, Jan Philipp Junker, Martin Falcke, Nikolaus Rajewsky   +4 more
doaj   +1 more source

Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer

Nature Communications, 2020
Prostate cancer is the second most commonly diagnosed malignancy among men worldwide. Recurrently mutated in primary and metastatic prostate tumors, FOXA1 encodes a pioneer transcription factor involved in disease onset and progression through both ...
Stanley Zhou, James R. Hawley, F. Soares, Giacomo Grillo, Mona Teng, S. A. Madani Tonekaboni, Junjie T Hua, Ken J. Kron, P. Mazrooei, Musaddeque Ahmed, C. Arlidge, Hwa Young Yun, J. Livingstone, Vincent Huang, Takafumi N. Yamaguchi, S. M. G. Espiritu, Yanyun Zhu, T. Severson, Alex Murison, S. Cameron, W. Zwart, T. H. van der Kwast, Trevor J Pugh, M. Fraser, P. Boutros, R. Bristow, H. He, M. Lupien   +27 more
semanticscholar   +1 more source

The problem field of design in urban renewal plans [PDF]

Nasleđe, 2016
The chosen planning approaches, the regulatory elements and building rules applied on individual plots have a considerable impact on the character and development of urban space.
Dimitrijević-Marković Svetlana
doaj   +1 more source

Evolution of hemoglobin loci and their regulatory elements. [PDF]

Blood Cells, Molecules, and Diseases, 2018
Across the expanse of vertebrate evolution, each species produces multiple forms of hemoglobin in erythroid cells at appropriate times and in the proper amounts. The multiple hemoglobins are encoded in two globin gene clusters in almost all species. One globin gene cluster, linked to the gene NPRL3, is preserved in all vertebrates, including a gene ...
S. Philipsen, R. Hardison
semanticscholar   +4 more sources

Computational prediction of splicing regulatory elements shared by Tetrapoda organisms [PDF]

, 2009
Background: auxiliary splicing sequences play an important role in ensuring accurate and efficient splicing by promoting or repressing recognition of authentic splice sites.
Churbanov, Alexander, Hicks, Chindo, Vořechovský, Igor   +2 more
core   +3 more sources

Ex vivo mapping of enhancer networks that define the transcriptional program driving melanoma metastasis

Molecular Oncology, 2023
Mortality from vmelanoma is associated with metastatic disease, but the mechanisms leading to spreading of the cancer cells remain obscure. Spatial profiling revealed that melanoma is characterized by a high degree of heterogeneity, which is established ...
Veronica Manicardi, Mila Gugnoni, Elisabetta Sauta, Benedetta Donati, Emanuele Vitale, Federica Torricelli, Gloria Manzotti, Simonetta Piana, Caterina Longo, Francesco Ghini, Alessia Ciarrocchi   +10 more
doaj   +1 more source

Theoretical analysis of the role of chromatin interactions in long-range action of enhancers and insulators [PDF]

, 2011
Long-distance regulatory interactions between enhancers and their target genes are commonplace in higher eukaryotes. Interposed boundaries or insulators are able to block these long distance regulatory interactions.
A. M. Sengupta, Arya, Banzhaf, Blackwood, Bondarenko, Bushey, Bustin, Capelson, Carter, Chodaparambil, Corces, Cremer, Cui, Dekker, Dorsett, Gerasimova, Geyer, Geyer, Hahnfeldt, Langowski, Luger, Moore, Nielsen, Nobrega, P. Schedl, Phair, Polikanov, Rochman, S. Mukhopadhyay, Savitskaya, Schermelleh, Simonis, Tolhuis, V. M. Studitsky, Valenzuela, van den Engh, Wallace, West, Zheng, Zhou   +39 more
core   +3 more sources

Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals

Cell Reports, 2015
Circular RNAs (circRNAs) are a large class of animal RNAs. To investigate possible circRNA functions, it is important to understand circRNA biogenesis. Besides human ALU repeats, sequence features that promote exon circularization are largely unknown. We
Andranik Ivanov, Sebastian Memczak, Emanuel Wyler, Francesca Torti, Hagit T. Porath, Marta R. Orejuela, Michael Piechotta, Erez Y. Levanon, Markus Landthaler, Christoph Dieterich, Nikolaus Rajewsky   +10 more
doaj   +1 more source

Predicting transcriptional responses to heat and drought stress from genomic features using a machine learning approach in rice

Frontiers in Plant Science, 2023
Plants have evolved various mechanisms to adapt to adverse environmental stresses, such as the modulation of gene expression. Expression of stress-responsive genes is controlled by specific regulators, including transcription factors (TFs), that bind to ...
Dajo Smet, Dajo Smet, Helder Opdebeeck, Helder Opdebeeck, Klaas Vandepoele, Klaas Vandepoele, Klaas Vandepoele   +6 more
doaj   +1 more source

Spatial clustering and common regulatory elements correlate with coordinated gene expression [PDF]

, 2019
Many cellular responses to surrounding cues require temporally concerted transcriptional regulation of multiple genes. In prokaryotic cells, a single-input-module motif with one transcription factor regulating multiple target genes can generate ...
Bai, Fan, Chen, Hengyu, Li, Ruoyan, Taft, David A., Xing, Jianhua, Yao, Guang, Zhang, Jingyu   +6 more
core   +3 more sources