Results 121 to 130 of about 1,838,349 (301)
Regulatory Harmonisation - Issues for New Zealand [PDF]
This paper discusses aspects of harmonisation of regulatory structures (occupational, product approval etc) between jurisdictions. The primary focus is on trans-national arrangements, but many of the issues also apply to relations between central and ...
Kevin Guerin
core
Edge usage, motifs and regulatory logic for cell cycling genetic networks
, 2013 The cell cycle is a tightly controlled process, yet its underlying genetic network shows marked differences across species. Which of the associated structural features follow solely from the ability to impose the appropriate gene expression patterns?
Krzywicki, A. +2 more
core +3 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
To Each Their Own: The Impact of Regulatory Focus on Consumers' Response to Online Information Load. [PDF]
Front Neurosci, 2022 Peng M, Xu Z, Huang H.
europepmc +1 more source
Technical Barriers to Interstate Trade: Noxious Weed Regulations [PDF]
We focus on regulations controlling the spread of noxious weeds, especially the trade effects of regulatory differences across U.S. states. We specify a gravity model for each state’s seed, nursery product, and commodity trade with each other state ...
Buccola, Steven T. +2 more
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
The role of product cues and regulatory focus in the consumers' response to green products: The mediation effects of green attitudes. [PDF]
Front Psychol, 2022 Wang X, Gu Y, Xin H, Qiu P, Wang J.
europepmc +1 more source
Brownfields Redevelopment in Wisconsin: Program, Citywide, and Site-Level Studies [PDF]
In this paper, the second installment of our three-part study on the development of brownfields policy in the state of Wisconsin, we use case studies to explore the implementation of the policy at three scales: 1) two statewide initiatives, the Voluntary
Hersh, Robert, Wernstedt, Kris
core
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source