Results 151 to 160 of about 1,838,349 (301)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

A study of the impact of message framing on calcium-rich foods intake in high school girls: a perspective of regulatory focus theory

open access: yesPayesh, 2016
Objective (s): The present study aimed to determine the impact of message framing on calcium-rich foods intake in high school girls using the regulatory focus theory.Methods: A random sample of students was selected and divided into 3 groups: a control ...
Haydeh Ghajari   +3 more
doaj  

An Analysis of the Tenth Government Report on the Costs and Benefits of Federal Regulations [PDF]

open access: yes
This paper critically reviews the draft of the Office of Management and Budget's tenth report on the benefits and costs of federal regulations. The draft report is similar to previous reports, and does not break new ground. We offer seven recommendations,
Hahn, Robert W., Litan, Robert E.
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

The role of the regulatory framework for innovation activities: The EU ETS and the German paper industry [PDF]

open access: yes
Based on a research framework which combines environmental economics and innovation studies, we explore the relevance of the regulatory framework for innovation activities in the German paper industry, with a focus on climate poli-cies.
Haussmann, Philipp   +4 more
core  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Inverting the regulatory rules? Optimizing airport regulation to account for commercial revenues [PDF]

open access: yes
This paper analyzes the role of commercial revenues in today's airport regulatory system. We find that the current regulatory regime only partially achieves core aims such as welfare maximization.
Evangelinos, Christos   +2 more
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

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