Results 21 to 30 of about 6,140,187 (206)

A Genomic Regulatory Network for Development

Science, 2002
Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory ...
Davidson, Eric H., Rast, Jonathan P., Oliveri, Paola, Ransick, Andrew, Calestani, Cristina, Yuh, Chiou-Hwa, Minokawa, Takuya, Amore, Gabriele, Hinman, Veronica, Arenas-Mena, César, Otim, Ochan, Brown, C. Titus, Livi, Carolina B., Lee, Pei Yun, Revilla, Roger, Rust, Alistair G., Pan, Zheng jun, Schilstra, Maria J., Clarke, Peter J. C., Arnone, Maria I., Rowen, Lee, Cameron, R. Andrew, McClay, David R., Hood, Leroy, Bolouri, Hamid   +24 more
openaire   +5 more sources

Quantum gene regulatory networks

npj Quantum Information, 2022
AbstractIn this work, we present a quantum circuit model for inferring gene regulatory networks (GRNs) from single-cell transcriptomic data. The model employs qubit entanglement to simulate interactions between genes, resulting in competitive performance and promising potential for further exploration.
Cristhian Roman-Vicharra, James J. Cai
openaire   +4 more sources

Identification of Key Genes Regulated by Lactylation Modification and Associated with Tumor Immune Microenvironment in Breast Cancer

Current Issues in Molecular Biology
Breast cancer (BRCA) is the most common cancer worldwide, with an incidence exceeding that of lung cancer. Protein lactylation, a newly identified post-translational modification involving the binding of lactic acid to lysine residues, plays an important
Yaohong Xie, Yi Ge, Na Miao, Pengxia Zhang, Jiaqi Xia   +4 more
doaj   +1 more source

Mitochondria-Targeted Fluorescent Nanoparticles with Large Stokes Shift for Long-Term BioImaging

Molecules, 2023
Mitochondria (MITO) play a significant role in various physiological processes and are a key organelle associated with different human diseases including cancer, diabetes mellitus, atherosclerosis, Alzheimer’s disease, etc.
Xiao Li, Tao Zhang, Xuebo Diao, Li Yu, Yue Su, Jiapei Yang, Zibo Shang, Shuai Liu, Jia Zhou, Guolin Li, Huirong Chi   +10 more
doaj   +1 more source

Comparative Study of Phellodendron amurense Rupr. Components in Alleviating Diabetic Kidney Disease via the PI3K/AKT/GSK-3β/Nrf2 Pathway

Pharmaceuticals
Background: To investigate the protective effects of Phellodendron amurense Rupr. polysaccharides (PAP), alkaloids, and flavonoids in alleviating diabetic kidney disease (DKD) and to elucidate the role of the PI3K/AKT/GSK-3β/Nrf2 signaling pathway ...
Mei Mei, Huawei Sun, Kai Zhang, Feng Zhang, Shiqing Sun, Enbin Yu, Yu Zhang   +6 more
doaj   +1 more source

Biomarker discovery studies for patient stratification using machine learning analysis of omics data: a scoping review

BMJ Open, 2021
Objective To review biomarker discovery studies using omics data for patient stratification which led to clinically validated FDA-cleared tests or laboratory developed tests, in order to identify common characteristics and derive recommendations for ...
Rita Banzi, Jacques Demotes, Paula Garcia, Enrico Glaab, Armin Rauschenberger, Chiara Gerardi   +5 more
doaj   +1 more source

Absolute quantification of DNA damage response proteins

Genes and Environment, 2023
Background DNA damage response (DDR) and repair are vital for safeguarding genetic information and ensuring the survival and accurate transmission of genetic material.
Shun Matsuda, Tsuyoshi Ikura, Tomonari Matsuda   +2 more
doaj   +1 more source

Analysis of the radiated electric field strength from in‐house G.fast2 data carrying wire‐line telecommunication network

IET Science, Measurement & Technology, 2021
G.fast profile 212a technology is the perfect choice for an operator offering a broadband service, as it operates using the existing copper telecommunications infrastructure (cables) already installed in user premises.
Josip Milanovic, Domagoj Budisa
doaj   +1 more source

A regulatory approach for the Australian charities and not-for-profit commission: A discussion paper [PDF]

, 2013
This discussion paper provides the basis for dialogue about a suitable regulatory framework for the not-for-profit sector (NFP).1 The purpose of regulation is to steer the flow of events.
Braithwaite, Valerie, Australian National University. Regulatory Institutions Network   +1 more
core  

The nucleolar shell provides anchoring sites for DNA untwisting

Communications Biology
DNA underwinding (untwisting) is a crucial step in transcriptional activation. DNA underwinding occurs between the site where torque is generated by RNA polymerase (RNAP) and the site where the axial rotation of DNA is constrained.
Jumpei Fukute, Koichiro Maki, Taiji Adachi   +2 more
doaj   +1 more source