Results 101 to 110 of about 7,752,988 (327)
Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion
Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana +8 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Regulatory Science and Regulatory Affairs
Journal of Regulatory Science, 2017 Regulatory science is a relatively new field of study and practice, brought about by the need to develop and apply tools and guidelines designed to give laws and regulations a solid scientific basis. Without a scientific basis, guidelines, laws, regulations, and standards would hardly be objective and able to withstand the scrutiny and opposition that ...
openaire +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Advancing regulatory science, advancing regulatory practice. [PDF]
Pharmacoepidemiology and drug safety, 2017 Kurz, Xavier
+5 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Journal of Regulatory Science, 2017 This paper describes the historical evolution of the Best Available Science concept leading to Best Available Regulatory Science (BARS) and Metrics for Evaluation of Regulatory Science Claims (MERSC). The paper identified five BARS Principles consisting of Open-mindedness, Skepticism, Scientific Rules, Ethical Rules, and Reproducibility.
Moghissi, Alan +3 more
openaire +1 more source
The medical science DMZ: a network design pattern for data-intensive medical science [PDF]
, 2017 : Objective We describe a detailed solution for maintaining high-capacity, data-intensive network flows (eg, 10, 40, 100 Gbps+) in a scientific, medical context while still adhering to security and privacy laws and regulations. Materials and Methods
Balas, Edward +8 more
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
NAM JournalTraditional regulatory frameworks for assessing the environmental safety of chemicals have historically focused on evaluating in vivo data from standard ecologically representative species.
Claudia Rivetti +7 more
doaj +1 more source