Results 111 to 120 of about 29,276,589 (300)

Labeling of Disease-Modifying Therapies for Neurodegenerative Disorders

Frontiers in Medicine, 2019
Neurodegenerative disorders are characterized by progressive degeneration of nerve cells resulting in functional decline of cognition and/or movement. As the prevalence of many of these disorders increases with the aging global population, there is an ...
Anne Vinther Morant, Vivien Jagalski, Henrik Tang Vestergaard   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Regulatory Science: Mathematical vs. Statistical Models

, 2016
Natural resource companies do not object to environmental regulations that are consistent and support predictability. Consistency and predictability are critical for decision making under conditions of uncertainty.
Shepard, Richard B
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Nuclear Regulatory Commission information digest

, 1990
The Nuclear Regulatory Commission information digest provides summary information regarding the US Nuclear Regulatory Commission, its regulatory responsibilities, and areas licensed by the commission.
None,
core   +1 more source

A real-world pharmacovigilance study on cardiovascular adverse events of tisagenlecleucel using machine learning approach

Scientific Reports
Chimeric antigen receptor T-cell (CAR-T) therapies are a paradigm-shifting therapeutic in patients with hematological malignancies. However, some concerns remain that they may cause serious cardiovascular adverse events (AEs), for which data are scarce ...
Juhong Jung, Ju Hwan Kim, Ji-Hwan Bae, Simon S. Woo, Hyesung Lee, Ju-Young Shin   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

PCSK9 Inhibitors and Infection-Related Adverse Events: A Pharmacovigilance Study Using the World Health Organization VigiBase

Drugs - Real World Outcomes
Aims Protein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are novel lipid-lowering agents used in patients with cardiovascular disease. Despite reassuring safety data from pivotal trials, increasing evidence from real-world studies suggests ...
Dahyun Park, Sungho Bea, Ji-Hwan Bae, Hyesung Lee, Young June Choe, Ju-Young Shin, Hoon Kim   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Federal Energy Regulatory Commission Report EIS-0016

, 1980
Supplement to a Final Environmental Impact Statement prepared by the staff of the Federal Energy Regulatory Commission that analyzes the engineering, environmental, and economic effects of amendments to the original proposal to abandon gas pipeline ...
United States. Federal Energy Regulatory Commission. Office of Pipeline and Producer Regulation
core