Results 111 to 120 of about 7,752,988 (327)

President Trump's war on regulatory science [PDF]

, 2019
The Trump Administration has taken numerous actions that appear hostile to scientists, scientific research, and scientific data, leading some observers to assert that a war on science is underway.
Lin, AC
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Labeling of Disease-Modifying Therapies for Neurodegenerative Disorders

Frontiers in Medicine, 2019
Neurodegenerative disorders are characterized by progressive degeneration of nerve cells resulting in functional decline of cognition and/or movement. As the prevalence of many of these disorders increases with the aging global population, there is an ...
Anne Vinther Morant, Vivien Jagalski, Henrik Tang Vestergaard   +2 more
doaj   +1 more source

Finite size corrections to random Boolean networks [PDF]

, 2006
Since their introduction, Boolean networks have been traditionally studied in view of their rich dynamical behavior under different update protocols and for their qualitative analogy with cell regulatory networks.
, Aldana Gonzalez M, Andrea Pagnani, Bayardo R J Schrag R C, Correale L, Derrida F, Dougherty E R, Giorgio Parisi, Hartmann A, Kauffman S, Michele Leone, Osvaldo Zagordi, Yedidia J S   +12 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Surrogate Endpoints in Pivotal Clinical Trials for Drug Approval in Japan Compared to the United States

Clinical and Translational Science
Regulatory guidance documents exist on surrogate endpoints in the United States. In Japan, there are no established rules or guidance regarding the use of surrogate endpoints, and various aspects remain unclear.
Yuko Yamamoto, Harumi Kosaka, Hanami Nojiri, Hideki Maeda   +3 more
doaj   +1 more source

Post-Moratorium EU Regulation of Genetically Modified Products: Trade Concerns [PDF]

Trade in genetically modified (GM) products remains a major issue in agricultural trade policy. In particular, the European Union has sought to deny market access to GM-products.
Kerr, William A., Viju, Crina, Yeung, May T.   +2 more
core   +1 more source

FDA-ARGOS is a database with public quality-controlled reference genomes for diagnostic use and regulatory science

Nature Communications, 2019
FDA proactively invests in tools to support innovation of emerging technologies, such as infectious disease next generation sequencing (ID-NGS). Here, we introduce FDA-ARGOS quality-controlled reference genomes as a public database for diagnostic ...
Heike Sichtig, T. Minogue, Yi Yan, C. Stefan, Adrienne T. Hall, L. Tallon, L. Sadzewicz, Suvarna Nadendla, W. Klimke, Eneida L. Hatcher, M. Shumway, Dayanara Lebron Aldea, Jonathan E. Allen, J. Koehler, T. Slezak, Stephen Lovell, R. Schoepp, U. Scherf   +17 more
semanticscholar   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

EPA Pats Itself on the Back [PDF]

The Environmental Protection Agency's report to Congress on the benefits and costs of the Clean Air Act from 1990 to 2010 is uninformative and unreliable.
Belzer, Richard B., Lutter, Randall
core   +1 more source