Results 91 to 100 of about 7,752,988 (327)

Healthcare resource utilisation and costs in infants with confirmed respiratory syncytial virus infections: a national population cohort study

BMC Infectious Diseases
Background Respiratory syncytial virus (RSV) is the leading cause of severe respiratory infections in infants worldwide, significantly affecting their health and contributing to the global healthcare burden.
Hyun Jin Han, Dahye Ryu, Ju Young Kim, Semin Jang, Hae Sun Suh   +4 more
doaj   +1 more source

Physiologically Based Pharmacokinetic Modeling in Regulatory Science: An Update From the U.S. Food and Drug Administration's Office of Clinical Pharmacology.

Journal of Pharmacy and Science, 2019
This commentary provides an update on the status of physiologically based pharmacokinetic modeling and simulation at the U.S. Food and Drug Administration's Office of Clinical Pharmacology. Limitations and knowledge gaps in integration of physiologically
Manuela Grimstein, Yuching Yang, Xinyuan Zhang, J. Grillo, Shiew-Mei Huang, I. Zineh, Yaning Wang   +6 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Accounting for Science: The Independence of Public Research in the New, Subterranean Administrative Law [PDF]

, 2003
The White House Office of Management and Budget (OMB) is putting the final touches on a system designed to account for the science used by federal agencies in their administrative missions.
Hornstein, Donald T.
core   +2 more sources

Misunderstanding Models in Environmental and Public Health Regulation [PDF]

, 2010
Computational models are fundamental to environmental regulation, yet their capabilities tend to be misunderstood by policymakers. Rather than rely on models to illuminate dynamic and uncertain relationships in natural settings, policymakers too often ...
Fisher, Elizabeth, Pascual, Pasky, Wagner, Wendy E.   +2 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Impact of a local formulary on prescribing patterns and pharmaceutical expenditure: an observational study in Japan

Journal of Pharmaceutical Health Care and Sciences
Background The implementation of local formularies in Japan began in November 2018 in the Sakata area of Yamagata Prefecture. A local formulary is a regional list of recommended pharmaceuticals selected based on comprehensive criteria, including efficacy,
Hirofumi Koike, Maho Taguchi, Akihiro Koide, Hiroaki Yamada   +3 more
doaj   +1 more source

Manufacturing Barriers to Biologics Competition and Innovation [PDF]

, 2016
As finding breakthrough small-molecule drugs gets harder, drug companies are increasingly turning to “large molecule” biologics. Although biologics represent many of the most promising new therapies for previously intractable diseases, they are extremely
Price, W. Nicholson, II, Rai, Arti K.
core   +2 more sources

Advancing UK regulatory science and innovation in healthcare

Journal of the Royal Society of Medicine, 2020
Melanie J Calvert , Eliot Marston, Mark Samuels, Samantha Cruz Rivera, Barbara Torlinska, Kathy Oliver, Alastair K Denniston and Steve Hoare Centre for Patient Reported Outcomes Research, Institute of Applied Health Research, University of Birmingham ...
M. Calvert, Eliot Marston, M. Samuels, Samantha Cruz Rivera, Barbara Torlinska, K. Oliver, A. Denniston, Steve Hoare   +7 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source