Results 71 to 80 of about 7,752,988 (327)

Robust H∞ feedback control for uncertain stochastic delayed genetic regulatory networks with additive and multiplicative noise [PDF]

, 2010
The official published version can found at the link below.Noises are ubiquitous in genetic regulatory networks (GRNs). Gene regulation is inherently a stochastic process because of intrinsic and extrinsic noises that cause kinetic parameter variations ...
Du, M, Gao, H, Li, Y, Pan, W, Wang, Z
core   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

3D Printed frames to enable reuse and improve the fit of N95 and KN95 respirators

BMC Biomedical Engineering, 2021
Background In response to supply shortages caused by the COVID-19 pandemic, N95 filtering facepiece respirators (FFRs or “masks”), which are typically single-use devices in healthcare settings, are routinely being used for prolonged periods and in some ...
Malia McAvoy, Ai-Tram N. Bui, Christopher Hansen, Deborah Plana, Jordan T. Said, Zizi Yu, Helen Yang, Jacob Freake, Christopher Van, David Krikorian, Avilash Cramer, Leanne Smith, Liwei Jiang, Karen J. Lee, Sara J. Li, Brandon Beller, Kimberley Huggins, Michael P. Short, Sherry H. Yu, Arash Mostaghimi, Peter K. Sorger, Nicole R. LeBoeuf   +21 more
doaj   +1 more source

What do stress tests test? Experimentation, demonstration, and the sociotechnical performance of regulatory science.

British Journal of Sociology, 2020
After their successful introduction during the 2007-2009 financial crisis, central bank stress tests were adopted as a fixture of international banking supervision.
N. Coombs
semanticscholar   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

In Silico Approach to Predict Severe Cutaneous Adverse Reactions Using the Japanese Adverse Drug Event Report Database

Clinical and Translational Science, 2021
Severe cutaneous adverse reactions (SCARs), such as Stevens–Johnson syndrome/toxic epidermal necrolysis and drug‐induced hypersensitivity syndrome, are rare and occasionally fatal.
Kaori Ambe, Kazuyuki Ohya, Waki Takada, Masaharu Suzuki, Masahiro Tohkin   +4 more
doaj   +1 more source

Pharmacists and Regulatory Science

YAKUGAKU ZASSHI, 2017
For providing appropriate pharmacotherapy, "Doing the right things, and doing things right" are necessary. Additionally, vigilance is required for the appropriate use of pharmaceuticals. Evidence-based medicine has been a common approach to healthcare, and many guidelines have been published. In addition, risk management plans (RMPs) are developed upon
openaire   +3 more sources

Establishing What Constitutes a Healthy Human Gut Microbiome: State of the Science, Regulatory Considerations, and Future Directions. [PDF]

, 2019
On December 17, 2018, the North American branch of the International Life Sciences Institute (ILSI North America) convened a workshop "Can We Begin to Define a Healthy Gut Microbiome Through Quantifiable Characteristics?" with >40 invited academic ...
Antonopoulos, Armitage, AVA, Singapore, Azad, Backhed, Barbara O Schneeman, Beaton, Beukers, Bindels, Bindels, Borewicz, Brazilian Health Regulatory Agency (ANVISA), Buddington, Cammarota, Campbell-Lendrum, Cantarel, Caporaso, Carlson, Cindy Davis, Claire M Fraser, Costea, Cummings, Curtis Huttenhower, Damen, Dao, David, David, Davis, Davoren, Desai, Deschasaux, Dethlefsen, De Preter, Earle, EFSA, EFSA, Eloe-Fadrosh, Esaiassen, European Commission, European Commission, Falony, FAO and WHO, FAO and WHO, FDA, FDA, FDA, FDA, FDA, FDA, FDA, FDA, FDA-NIH Biomarker Working Group, Fedacko, Fei, Ferretti, Fischbach, Flaherman, Flint, Forbes, Foster, Fragiadakis, Francois, François, François, Gibson, Government of Canada, Gregory, Gupta, Hadizadeh, He, Health Canada, Health Canada, Health Canada, Health Canada, Health Canada, Health Canada, Hermansson, Hildebrand, Ho, Holmes, Holmes, Holscher, Insel, Jacobsen, Jakobsson, Jangi, Janssens, Japan Consumer Affairs Agency, Japan Consumer Affairs Agency, Japan Ministry of Health, Labour, and Welfare, Japan Ministry of Health, Labour, and Welfare, Jens Walter, Jones, Kennedy, Koenig, Korpela, Kristensen, Kristin Verbeke, Kritchevsky, Krumbeck, Lahti, Lam, Langdon, Lawley, La Fata, Leiby, Lim, Lloyd-Price, Lohner, Lozupone, Makki, Maldonado-Gómez, Marcobal, Marie E Latulippe, Martin, Martinez, Martínez, Martínez, Martínez, Matamoros, McBurney, McBurney, McBurney, McFarland, Michael I McBurney, Miller, MOH Malaysia, MOH Malaysia, MOPH Thailand, Mould, Mueller, NDAC, Palleja, Perez-Muñoz, Rattanaprasert, Roager, Robb, Rothschild, Round, Russell, Rutishauser, Saxelin, Schloissnig, Schlomann, Schneeberger, Schroeder, Snijder, Song, Sonnenburg, Sonnenburg, Sprockett, Sundin, Surana, Tanemura, Tannock, Taverniti, The Human Microbiome Project Consortium, Tremlett, Trowell, Vandeputte, Vangay, Vatanen, Vellend, Venkataraman, Venkataraman, Voigt, von Wintzingerode, Walter, Wan, Wang, Watson, Wedekind, Windey, Windey, Windey, Wong, Wu, Yassour   +177 more
core   +2 more sources

The GTEx Consortium atlas of genetic regulatory effects across human tissues

Science, 2019
The Genotype-Tissue Expression (GTEx) project was established to characterize genetic effects on the transcriptome across human tissues and to link these regulatory mechanisms to trait and disease associations.
F. Aguet, A. Barbeira, Rodrigo Bonazzola, A. Brown, S. Castel, Brian Jo, S. Kasela, Sarah Kim-Hellmuth, Yanyu Liang, Meritxell Oliva, P. Parsana, Elise D. Flynn, L. Frésard, Eric R Gaamzon, Andrew R. Hamel, Yuan He, F. Hormozdiari, P. Mohammadi, Manuel Muñoz-Aguirre, YoSon Park, A. Saha, Ayellet V Segrć, B. Strober, Xiaoquan Wen, Valentin Wucher, Sayantani Das, D. Garrido-Martín, Nicole R. Gay, R. Handsaker, Paul J. Hoffman, Seva Kashin, Alan M. Kwong, Xiao Li, D. MacArthur, J. Rouhana, M. Stephens, E. Todres, A. Viñuela, Gao Wang, Yuxin Zou, Christopher D. Brown, N. Cox, E. Dermitzakis, B. Engelhardt, G. Getz, R. Guigó, S. Montgomery, B. Stranger, H. Im, A. Battle, K. Ardlie, T. Lappalainen   +51 more
semanticscholar   +1 more source

Translation of Digital Health Technologies to Advance Precision Medicine: Informing Regulatory Science

Digital Biomarkers, 2020
The proliferation of digital technologies and the application of sophisticated data analysis techniques are increasingly viewed as having the potential to transform translational research and precision medicine.
Joan E. Adamo, Robert V. Bienvenu II, Felipe Dolz, M. Liebman, Wendy Nilsen, Scott J. Steele   +5 more
semanticscholar   +1 more source