Results 61 to 70 of about 11,560,234 (287)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Investigating age-related dynamics and transcriptional signatures of CD8⁺HLA-DR⁺ regulatory T lymphocytes: perspectives in understanding immune system aging

Медицинская иммунология
The ability of the CD8+HLA-DR+ regulatory T lymphocytes population to regulate the immune response was first described several years ago. It is known that the suppressive effects of these cells depend on intercellular interactions and are mediated by the
K. S. Matveeva, S. A. Rybtsov, D. V. Shevyrev   +2 more
doaj   +1 more source

Decrease of Tumor-infiltrating Regulatory T Cells Using Pentoxifylline: An Ex Vivo Analysis in Triple-negative Breast Cancer Mouse Model

Iranian Journal of Allergy, Asthma and Immunology, 2022
Triple-negative breast cancer (TNBC) is the most aggressive type of BC with the highest percentage of tumor-infiltrating lymphocytes (TILs). Hence, TIL therapy is considered a promising approach to target TNBC. Depletion of regulatory T cells (Tregs) in
Mohammad Hossein Kazemi, Mahdieh Shokrollahi Barough, Alireza Ghanavatinejad, Zahra Momeni-Varposhti, Samaneh Khorrami, Behnam Sadeghi, Reza Falak   +6 more
doaj  

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

IL-24 producing regulatory T and B lymphocytes in endometriosis

Frontiers in Immunology
ProblemUnbalanced production of pro- and anti-inflammatory cytokines by immune cells is a hallmark of endometriosis. IL-24, a member of the IL-10 family, is a pleiotropic cytokine produced by both non-immune cells like astrocytes, keratinocytes ...
Anna Ewa Kedzierska, Daria Lorek, Anna Slawek, Mikolaj Karmowski, Aleksandra Kalota, Jaroslaw Pajak, Jaroslaw Pajak, Agnieszka Chrobak, Krzysztof Grzymajlo, Anna Chelmonska-Soyta   +9 more
doaj   +1 more source

Cyclin kinase inhibitor p21: a mediator of immune tolerance: direct and indirect evidence [PDF]

, 2009
*Background:* Uncontrolled proliferation of T-cells is considered a barrier to the induction of transplantation tolerance by T regulatory cells. Therefore, cyclin kinase inhibitor p21, one of the most potent inhibitors of cell proliferation, may exert an
Ashwani Khanna
core  

Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope [PDF]

, 1991
The regulatory immediate-early (IE) protein pp89 of murine cytomegalovirus induces CD8+ T lymphocytes that protect against lethal murine cytomegalovirus infection.
Ulrich, H. Koszinowski, Koszinowski, Ulrich H., Messerle, Martin, Matthias J. Reddehase, Hansjurgen Volkmer, Reddehase, Matthias J., Del Val, Margarita, Margarita Del Val, Martin Messerle, Volkmer, Hansjürgen, Hans-jurgen Schlicht, Schlicht, Hans-Jürgen   +12 more
core   +1 more source

The use of wavelength modulated Raman spectroscopy in label-free identification of T lymphocyte subsets, natural killer cells and dendritic cells [PDF]

, 2015
This work was funded by a Cancer Research United Kingdom, Engineering and Physical Sciences Research Council (grant EP/J01771X/1), Medical Research Council and Department of Health England Imaging Programme (MC, MM KD), and by A European Union FAMOS ...
Barbosa, Joao, Campbell, Elaine Catherine, Naomi McReynolds (741700), Michael Mazilu (426524), Dholakia, Kishan, Kishan Dholakia, João Barbosa (741701), Simon J. Powis (319937), Elaine C. Campbell (319934), Mazilu Michael, McReynolds Naomi, Dholakia Kishan, McReynolds, Naomi, Simon J Powis, Campbell Elaine C., Powis Simon J., Elaine C Campbell, Mingzhou Chen, Naomi McReynolds, Kishan Dholakia (426528), Chen Mingzhou, João Barbosa, Mingzhou Chen (741699), Barbosa João, Michael Mazilu, Chen, Mingzhou, Mazilu, Michael, Powis, Simon John   +27 more
core   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Regulatory T cells in children with recently diagnosed type 1 diabetes

Indian Journal of Endocrinology and Metabolism, 2012
Background: Regulatory T cells have an important role in the control of immune reactivity against self antigens and probably play a role in pathogenesis of type 1 diabetes (T1D).
Asmaa Mohamed Zahran, Khalid Ibrahem Elsayh, Kotb Abbass Metwalley   +2 more
doaj   +1 more source